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首页> 外文期刊>Trends in Microbiology >Gaining ground: assays for therapeutics against botulinum neurotoxin
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Gaining ground: assays for therapeutics against botulinum neurotoxin

机译：取得进展：针对肉毒杆菌神经毒素的疗法的检测方法

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摘要

Owing in part to recently heightened concern over bio-terrorism, interest in the mechanism of action of botulinum neurotoxin (BoNT) and development of effective therapeutic strategies has dramatically increased. The emergence of BoNT as an effective treatment for a variety of neurological disorders and its growing use in the cosmetic industry have also increased interest in developing effective countermeasures. Although recent attempts to create effective vaccines appear promising, the multitude of clinical and cosmetic uses of BoNT make mass vaccination against the toxin undesirable and impractical, leading to intensified efforts to develop effective therapeutics to combat large-scale intoxications. In this review, we examine the relevant and available in vitro cell-based assays and in vivo assays for drug discovery and development, especially with regard to the potential for medium- to high-throughput automation and its use in identifying physiologically relevant inhibitors.
机译：由于最近对生物恐怖主义的日益关注，对肉毒杆菌神经毒素（BoNT）的作用机制和有效治疗策略的发展的兴趣已大大增加。 BoNT作为多种神经系统疾病的有效治疗方法的出现及其在化妆品行业中的广泛使用，也引起了人们对开发有效对策的兴趣。尽管最近尝试创建有效疫苗的尝试似乎很有希望，但BoNT的大量临床和美容用途使针对该毒素的大规模疫苗接种不合需要且不切实际，从而导致人们加大了开发有效疗法来对抗大规模中毒的努力。在这篇综述中，我们研究了相关的和可用的体外基于细胞的测定法和体内测定法，用于药物发现和开发，特别是关于中至高通量自动化的潜力及其在鉴定生理相关抑制剂中的用途。

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