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首页> 外文期刊>Trends in Microbiology >Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
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Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance

机译：肠道菌群与宿主之间的相互作用对难辨梭状芽孢杆菌的定殖性产生影响

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摘要

Clostridium difficile infection (CDI) has become one of the most prevalent and costly nosocomial infections. In spite of the importance of CDI, our knowledge of the pathogenesis of this infection is still rudimentary. Although previous use of antibiotics is generally considered to be the sine qua non of CDI the mechanisms by which antibiotics render the host susceptible to C. difficile are not well defined. In this review, we will explore what is known about how the indigenous microbiota acts in concert with the host to prevent colonization and virulence of C. difficile and how antibiotic administration disturbs host microbiota homeostasis, leading to CDI.
机译：艰难梭菌感染（CDI）已成为最普遍和最昂贵的医院感染之一。尽管CDI非常重要，但我们对这种感染的发病机理的了解仍很初级。尽管通常认为以前使用抗生素是CDI的必要条件，但尚不清楚抗生素使宿主易患艰难梭菌的机制。在这篇综述中，我们将探索有关土著微生物群如何与宿主协同作用以预防艰难梭菌的定殖和毒力以及抗生素管理如何干扰宿主微生物群稳态从而导致CDI的已知知识。

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