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首页> 外文期刊>Trends in Microbiology >HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design
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HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design

机译：来自感染和疫苗接种的HIV-1抗体：指导疫苗设计的见解

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摘要

Attempts to formulate a protective HIV-1 vaccine through classic vaccine design strategies have not been successful. Elicitation of HIV-1-specific broadly neutralizing antibodies (bnAbs) at high titers that are present before exposure might be required to achieve protection. Recently, the application of new technologies has facilitated the study of clonal lineages of HIV-1 envelope (Env) antibodies, which have provided insights into HIV-1 antibody development during infection and upon vaccination. Strategies are being developed for the analysis of infection and vaccine candidate-induced antibodies, their gene usage, and their maturation pathways such that this information can be used to attempt to guide rational vaccine design.
机译：通过经典疫苗设计策略来配制保护性HIV-1疫苗的尝试尚未成功。为了获得保护，可能需要在暴露前以高滴度洗脱HIV-1特异性广泛中和抗体（bnAb）。最近，新技术的应用促进了HIV-1包膜（Env）抗体克隆谱系的研究，这为感染期间和疫苗接种后HIV-1抗体的发展提供了见识。正在开发用于分析感染和疫苗候选物诱导的抗体，其基因使用及其成熟途径的策略，以便可以使用此信息来尝试指导合理的疫苗设计。

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