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Can the battle against tuberculosis gain from epigenetic research?

机译:表观遗传学研究能否战胜结核病?

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摘要

A healthy immune system needs to be highly plastic to cope with host defense and surveillance. What mechanisms provide this plasticity? Considering the threat of infectious diseases to a large part of the world's population, can these mechanisms possibly be of use in the ongoing battle against infectious diseases? Against the backdrop of the pandemic nature of tuberculosis, we discuss whether and how epigenetic mechanisms can shed light on our understanding of infectious disease, and if epigenetic marks can be employed to monitor latent infection, disease reactivation or treatment response.
机译:一个健康的免疫系统需要高度可塑性,以应对宿主的防御和监视。哪些机制可提供这种可塑性?考虑到传染病对世界大部分人口的威胁,这些机制是否可能在正在进行的与传染病的斗争中使用?在结核病大流行的背景下,我们讨论了表观遗传机制是否以及如何阐明我们对传染病的理解,以及表观遗传标记是否可以用于监测潜伏感染,疾病再激活或治疗反应。

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