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When the PilZ don't work: effectors for cyclic di-GMP action in bacteria

机译:当PilZ不起作用时:细菌中循环双GMP作用的效应子

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摘要

The second messenger cyclic di-GMP has emerged as a central regulator of many important bacterial processes including biofilm formation and virulence. Although the pathways of cyclic di-GMP synthesis and degradation have been established, the mechanisms by which this second messenger exerts its action on diverse cellular functions remain relatively poorly understood. Recent studies report considerable advances in identifying different classes of cyclic di-GMP effectors; these include the PilZ protein domain, transcription factors, proteins involved in RNA processing and riboswitches. Here, we review this range of cyclic di-GMP effectors and the biological processes that they govern using examples from several different bacteria.
机译:第二信使环二GMP已成为许多重要细菌过程(包括生物膜形成和毒力)的中央调节剂。尽管已经建立了环状双GMP合成和降解的途径,但该第二信使对多种细胞功能发挥作用的机制仍然知之甚少。最近的研究表明,在鉴定不同类别的循环双GMP效应子方面取得了长足进展。这些包括PilZ蛋白结构域,转录因子,RNA加工中涉及的蛋白和核糖开关。在这里,我们使用几种不同细菌的实例,回顾了这一范围的环状双GMP效应子及其控制的生物学过程。

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