Bacterial mechanosensitive channels: integrating physiology, structure and function

Paul Blount; Paul C. Moe

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Bacterial mechanosensitive channels: integrating physiology, structure and function

机译：细菌机械敏感通道：整合生理，结构和功能

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When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived form X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension.

机译：当面对低渗胁迫时，许多细菌物种能够通过将细胞质溶质通过膜张力门控通道抛入培养基中，从而迅速适应细胞膨胀压力的增加。生理研究已证实这些通道在渗透调节中的重要性。这些通道之一的诱变作用，结合从X射线晶体学得出的结构信息，已经给出了机械敏感通道如何感测和响应膜张力的最初线索。

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来源
《Trends in Microbiology》 |1999年第10期|共4页
作者
Paul Blount; Paul C. Moe;
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原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词
stress; jettisoning; channels; mechanosensitive;

机译：应力;Jettisoning;通道;机械敏感;

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1. Bacterial mechanosensitive channels: integrating physiology, structure and function. [J] . Blount P, Moe PC Trends in Microbiology . 1999,第10期

机译：细菌机械敏感通道：整合生理，结构和功能。
2. Bacterial mechanosensitive channels: integrating physiology, structure and function [J] . Paul Blount, Paul C. Moe Trends in Microbiology . 1999,第10期

机译：细菌机械敏感通道：整合生理，结构和功能
3. Structure and function of the bacterial mechanosensitive channel of large conductance. [J] . Oakley AJ, Martinac B, Wilce MC Protein Science: A Publication of the Protein Society . 1999,第10期

机译：大电导的细菌机械敏感通道的结构和功能。
4. Sensing bilayer tension: bacterial mechanosensitive channels and their gating mechanisms [C] . Ian R. Booth, Tim Rasmussen, Michelle D. Edwards Biochemical Society Annual Symposium . 2011

机译：传感双层张力：细菌机械敏感通道及其门控机构
5. The gating of the bacterial mechanosensitive channel MscS reflects its function as a sensor of both crowding and lateral pressure as well as its role in osmoregulation. [D] . Rowe, Ian Donald. 2014

机译：细菌机械敏感通道MscS的门控反映了其作为拥挤和侧向压力传感器的功能以及其在渗透压调节中的作用。
6. Structure and function of the bacterial mechanosensitive channel of large conductance. [O] . A. J. Oakley, B. Martinac, M. C. Wilce 1999

机译：大电导的细菌机械敏感通道的结构和功能。
7. Structure and function of the bacterial mechanosensitive channel of large conductance. [O] . Oakley, A. J., Martinac, B., Wilce, M. C. 1999

机译：大电导的细菌机械敏感通道的结构和功能。
8. Mechanosensitive Ion Channels in Bacteria: Functional Domains and Mechanisms of Gating [R] . Sukharev, Sergei 2003

机译：细菌中的机械敏感离子通道：功能域和门控机制

Bacterial mechanosensitive channels: integrating physiology, structure and function

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