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Guards of the great wall: bacterial lysozyme inhibitors

机译:长城守卫:细菌溶菌酶抑制剂

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Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly specific bacterial proteinaceous lysozyme inhibitors against the three major animal lysozyme families have been discovered in bacteria, and these may represent a bacterial answer to animal lysozymes. Here, we will review their properties and phylogenetic distribution, present their structure and molecular interaction mechanism with lysozyme, and discuss their possible biological functions and potential applications.
机译:肽聚糖是细菌细胞壁的主要结构成分。它提供了抗膨胀性的能力,并被水解酶(如溶菌酶)切割而导致细菌分解。大多数(如果不是全部)动物产生溶菌酶,作为其先天免疫系统的关键效应物。最近,在细菌中发现了针对三种主要动物溶菌酶家族的高度特异性细菌蛋白溶菌酶抑制剂,这些抑制剂可能代表了动物溶菌酶的细菌反应。在这里,我们将审查其性质和系统发育分布,介绍其结构和与溶菌酶的分子相互作用机制,并讨论其可能的生物学功能和潜在应用。

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