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Tubercle bacilli rely on a type VII army for pathogenicity

机译:结核杆菌的致病性依赖于VII型军队

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Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secretion (T7S) pathway has been identified that fulfills this function. Pathogenic mycobacteria have up to five different T7S systems, some of which play a crucial role in virulence. The interactions between secreted substrates and host molecules are only starting to become clear and will help in furthering our understanding of the persistence of these enigmatic pathogens. In this review, we discuss current knowledge on the role of T7S systems in mycobacterial virulence.
机译:分枝杆菌,例如主要的人类病原体结核分枝杆菌,具有高度异常和特征性的干细胞包膜,可以保护它们免受有害条件的侵害。跨此疏水性屏障的蛋白质分泌需要专门的分泌系统。最近,已经确定了实现该功能的VII型分泌(T7S)途径。致病性分枝杆菌最多具有五个不同的T7S系统,其中一些在毒力中起关键作用。分泌的底物与宿主分子之间的相互作用才刚刚开始变得清晰,这将有助于我们进一步了解这些神秘病原体的持久性。在这篇综述中,我们讨论了有关T7S系统在分枝杆菌毒力中作用的最新知识。

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