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首页> 外文期刊>Trends in Microbiology >Decoding the complexity of type I interferon to treat persistent viral infections
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Decoding the complexity of type I interferon to treat persistent viral infections

机译：解码I型干扰素治疗持续性病毒感染的复杂性

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摘要

Type I interferons (IFN-I) are a broad family of cytokines that are central to the innate immune response. These proteins have long been appreciated for the critical roles they play in restraining viral infections and shaping antiviral immune responses. However, in recent years there has been increased awareness of the immunosuppressive actions of these proteins as well. Although there are many current therapeutic applications to manipulate IFN-I pathways, we have limited understanding of the mechanisms by which these therapies are actually functioning. In this review, we highlight the diversity and temporal impact of IFN-I signaling, discuss the current therapeutic uses of IFN-I, and explore the strategy of blocking IFN-I to alleviate immune dysfunction in persistent virus infections.
机译：I型干扰素（IFN-I）是广泛的细胞因子家族，对于先天免疫反应至关重要。长期以来，人们一直赞赏这些蛋白质在抑制病毒感染和塑造抗病毒免疫反应中所起的关键作用。但是，近年来，对这些蛋白质的免疫抑制作用的认识也增加了。尽管目前有许多治疗方法可操纵IFN-I途径，但我们对这些疗法实际发挥作用的机制了解有限。在这篇综述中，我们重点介绍了IFN-I信号的多样性和暂时性影响，讨论了IFN-I的当前治疗用途，并探讨了阻断IFN-I减轻持久性病毒感染中免疫功能障碍的策略。

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