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Mechanisms of endospore inactivation under high pressure

机译:高压下孢子失活的机理

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It is well known that spore germination and inactivation can be achieved within a broad temperature and pressure range. The existing literature, however, reports contradictory results concerning the effectiveness of different pressure-temperature combinations and the underlying inactivation mechanism(s). Much of the published kinetic data are prone to error as a result of unstable process conditions or an incomplete investigation of the entire inactivation pathway. Here, we review this field of research, and also discuss an inactivation mechanism of at least two steps and propose an inactivation model based on current data. Further, spore resistance properties and matrix interactions are linked to spore inactivation effectiveness.
机译:众所周知,可以在较宽的温度和压力范围内实现孢子萌发和灭活。然而,现有文献报道了关于不同压力-温度组合的有效性和潜在的失活机理的矛盾结果。由于不稳定的工艺条件或对整个灭活途径的不完全研究,许多公开的动力学数据容易出错。在这里,我们回顾了这一研究领域,还讨论了至少两个步骤的灭活机制,并提出了基于当前数据的灭活模型。此外,孢子抗性和基质相互作用与孢子灭活效果有关。

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