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首页> 外文期刊>Trends in Microbiology >Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development
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Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development

机译：结核分枝杆菌分泌的磷酸酶：从发病机理到结核病药物开发的靶标

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摘要

Mycobacterium tuberculosis (Mtb) infects human alveolar macrophages and relies on the inhibition of phagosome acidification and maturation. This is, in part, dependent on the disruption of host signaling networks within the macrophage. In recent years, Mtb-secreted protein- and lipid-phosphatases protein-tyrosine phosphatase A (PtpA), PtpB, and secreted acid phosphatase M (SapM) have been shown to contribute to Mtb pathogenicity. Here, we review the current knowledge on PtpA, PtpB, and SapM focusing on their ability to interfere with host functions. We further explore how these phosphatase-dependent host-pathogen interactions can be targeted for novel tuberculosis (TB) drug discovery and examine the ongoing development of inhibitors against these phosphatases.
机译：结核分枝杆菌（Mtb）感染人类肺泡巨噬细胞，并依赖于抑制吞噬体酸化和成熟。这部分取决于巨噬细胞内宿主信号网络的破坏。近年来，已显示出Mtb分泌的蛋白和脂质磷酸酶蛋白-酪氨酸磷酸酶A（PtpA），PtpB和分泌的酸性磷酸酶M（SapM）有助于Mtb的致病性。在这里，我们将重点介绍PtpA，PtpB和SapM干扰宿主功能的能力。我们进一步探索这些磷酸酶依赖性宿主-病原体相互作用如何可以针对新型结核病（TB）药物发现，并检查针对这些磷酸酶的抑制剂的持续开发。

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