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Structure and function of the human skin microbiome.

机译:人类皮肤微生物组的结构和功能。

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摘要

An abundant and diverse collection of bacteria, fungi, and viruses inhabits the human skin. These microorganisms vary between individuals and between different sites on the skin. The factors responsible for the unique variability of the skin microbiome are only partly understood, but results suggest that host genetic and environmental influences play a major role. Today, the steady accumulation of data describing the skin microbiome, combined with experiments designed to test the biological functions of surface microbes, has provided new insights into links between human physiology and skin microbiota. This review describes some of the current information regarding the skin microbiome and its impact on human health. Specifically, we summarize the present understanding of the function of microbe-host interactions on the skin and highlight some unique features that distinguish skin commensal organisms from pathogenic microbes.
机译:人类的皮肤中栖息着丰富多样的细菌,真菌和病毒。这些微生物在个体之间以及在皮肤上的不同部位之间都不同。造成皮肤微生物组独特变异的因素仅被部分理解,但结果表明宿主的遗传和环境影响起主要作用。如今,描述皮肤微生物组的数据不断积累,再加上旨在测试表面微生物的生物学功能的实验,为人们生理学与皮肤微生物群之间的联系提供了新见解。这篇评论描述了有关皮肤微生物组及其对人类健康影响的一些当前信息。具体来说,我们总结了目前对微生物与宿主的相互作用在皮肤上的功能的理解,并突出了区分皮肤共生生物与病原微生物的一些独特功能。

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