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Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors

机译:III型分泌系统效应子对运输,凋亡和先天免疫的破坏

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摘要

Injection of effector proteins by a type III secretion system (T3SS) is a common infection strategy employed by many important human pathogens, including enteric Escherichia coil, Salmonella, Yersinia, and Shigella, to subvert cell signaling and host responses. In recent years, great advances have been made in understanding how the T3SS effectors function and execute the diverse infection strategies employed by these pathogens. In this review, we focus on effectors that subvert signaling pathways that impact on endosomal trafficking, cell survival, and innate immunity, particularly phagocytosis, nuclear factor-kappa B (NF-kappa B), and mitogen-activated protein (MAP) kinase pathways and the inflammasome.
机译:通过III型分泌系统(T3SS)注入效应蛋白是许多重要的人类病原体(包括肠大肠埃希菌,沙门氏菌,耶尔森氏菌和志贺氏菌)采用的常见感染策略,以破坏细胞信号传导和宿主反应。近年来,在了解T3SS效应子如何发挥作用并执行这些病原体采用的多种感染策略方面取得了很大的进步。在这篇综述中,我们集中于颠覆影响内体运输,细胞存活和先天免疫的信号通路的效应子,特别是吞噬作用,核因子-κB(NF-κB)和促分裂原活化蛋白(MAP)激酶通路和炎症。

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