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Bat-derived influenza-like viruses H17N10 and H18N11.

机译:蝙蝠衍生的流感样病毒H17N10和H18N11。

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Shorebirds and waterfowls are believed to be the reservoir hosts for influenza viruses, whereas swine putatively act as mixing vessels. The recent identification of two influenza-like virus genomes (designated H17N10 and H18N11) from bats has challenged this notion. A crucial question concerns the role bats might play in influenza virus ecology. Structural and functional studies of the two major surface envelope proteins, hemagglutinin (HA) and neuraminidase (NA), demonstrate that neither has canonical HA or NA functions found in influenza viruses. However, putative functional modules and domains in other encoded proteins are conserved, and the N-terminal domain of the H17N10 polymerase subunit PA has a classical structure and function. Therefore, potential genomic reassortments of such influenza-like viruses with canonical influenza viruses cannot be excluded at this point and should be assessed.
机译:人们认为水鸟和水禽是流感病毒的宿主,而猪则被认为是混合容器。最近从蝙蝠中鉴定出两个类似流感的病毒基因组(命名为H17N10和H18N11)挑战了这一概念。一个关键问题涉及蝙蝠在流感病毒生态学中可能发挥的作用。对两种主要表面包膜蛋白,血凝素(HA)和神经氨酸酶(NA)的结构和功能研究表明,在流感病毒中均未发现规范的HA或NA功能。但是,保守的功能模块和其他编码的蛋白质中的域是保守的,并且H17N10聚合酶亚基PA的N末端域具有经典的结构和功能。因此,此时不能排除此类流感样病毒与标准流感病毒的潜在基因组重配,应进行评估。

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