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Through the looking glass: witnessing host-virus interplay in zebrafish

机译:透过窥视镜:见证斑马鱼中宿主病毒的相互作用

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Host-pathogen interactions can be very complex at all scales; understanding organ- or organism-level events require in vivo approaches. Besides traditional host models such as mice, the zebrafish offers an attractive cocktail of optical accessibility and genetic tractability, blended with a vertebrate-type immunity, where innate responses can easily be separated from adaptive ones. Applied to viral infections, this model has revealed unexpected idiosyncrasies among organs, which we believe may apply to the human situation. We also argue that the dynamic analysis of virus spread and immune response in zebrafish make this model particularly well suited to the exploration of the concept of infection tolerance and resistance in relation to viral diseases
机译:宿主-病原体的相互作用在各个层面上都可能非常复杂。了解器官或生物体水平的事件需要体内方法。除了小鼠等传统宿主模型外,斑马鱼还具有吸引人的光学可及性和遗传易处理性,并融合了脊椎动物的免疫力,可将先天性反应与适应性反应轻松区分开。应用于病毒感染后,该模型揭示了器官之间意想不到的特质,我们认为这可能适用于人类情况。我们还认为,对斑马鱼中病毒传播和免疫反应的动态分析使该模型特别适合于探索与病毒性疾病有关的感染耐受性和耐药性的概念。

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