首页> 外文期刊>Trends in Microbiology >Programmed necrosis in microbial pathogenesis
【24h】

Programmed necrosis in microbial pathogenesis

机译:微生物病程中的程序性坏死

获取原文
获取原文并翻译 | 示例
           

摘要

Programmed cell death is an important facet of host-pathogen interactions. Although apoptosis has long been implicated as the major form of programmed cell death in host defense, the past decade has seen the emergence of other forms of regulated death, including programmed necrosis. While the molecular mechanisms of programmed necrosis continue to be unveiled, an increasing number of viral and bacterial pathogens induce this form of death in host cells, with important consequences for infection, control, and pathogenesis. Moreover, pathogen strategies to manipulate or utilize this pathway are now being discovered. In this review, we focus on a variety of viral and bacterial pathogens where a role for programmed necrosis is starting to be appreciated. In particular, we focus on the mechanistic details of how the host or the pathogen might appropriate this pathway for its own benefit.
机译:程序性细胞死亡是宿主-病原体相互作用的重要方面。尽管细胞凋亡早已被认为是宿主防御中程序性细胞死亡的主要形式,但在过去的十年中,出现了其他形式的调节性死亡,包括程序性坏死。尽管程序性坏死的分子机制不断被揭示,但越来越多的病毒和细菌病原体在宿主细胞中诱导了这种形式的死亡,对感染,控制和发病机理具有重要意义。而且,现在正在发现操纵或利用该途径的病原体策略。在这篇综述中,我们集中于各种病毒和细菌病原体,其中程序性坏死的作用已开始被人们所认识。特别是,我们专注于宿主或病原体可能如何利用此途径以实现自身利益的机制细节。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号