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首页> 外文期刊>Trends in Microbiology >New insights into the crosstalk between Shigella and T lymphocytes
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New insights into the crosstalk between Shigella and T lymphocytes

机译：志贺氏菌与T淋巴细胞之间的串扰的新见解

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摘要

Subversion of host immune responses is the key infection strategy employed by most, if not all, human pathogens. Modulation of the host innate response by pathogens has been vastly documented. Yet, especially for bacterial infections, it was only recently that cells of the adaptive immune response were recognized as targets of bacterial weapons such as the type III secretion system (T3SS) and its effector proteins. In this review, we focus on the recent advances made in the understanding of how the enteroinvasive bacterium Shigella flexneri interferes with the host adaptive response by targeting T lymphocytes, especially their migration capacities.
机译：破坏宿主免疫反应是大多数（如果不是全部）人类病原体采用的关键感染策略。病原体对宿主先天反应的调节已被大量记载。然而，尤其是对于细菌感染，直到最近才将适应性免疫反应的细胞识别为细菌武器的靶标，例如III型分泌系统（T3SS）及其效应蛋白。在这篇综述中，我们集中在了解肠侵袭性细菌弗氏志贺氏菌如何通过靶向T淋巴细胞，特别是其迁移能力来干扰宿主适应性反应方面取得的最新进展。

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