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首页> 外文期刊>Trends in Microbiology >Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids
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Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids

机译：金黄色葡萄球菌成孔毒素对细胞的靶向作用：不仅涉及脂质

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摘要

Staphylococcus aureus employs numerous pore-forming cytotoxins to injure host immune cells and promote infection. Until recently, it was unclear how these cytotoxins targeted specific cell types for lysis. Membrane lipids were initially postulated to be cytotoxin receptor candidates. However, the cell-type specificity and species-dependent targeting of these toxins did not support lipids as sole receptors. The recent identification of proteinaceous receptors for several S. aureus cytotoxins now provides an explanation for the observed tropism. These findings also have important implications for the implementation of animal models to study S. aureus pathogenesis, and for the development of novel therapeutics.
机译：金黄色葡萄球菌利用许多成孔性细胞毒素来伤害宿主免疫细胞并促进感染。直到最近，还不清楚这些细胞毒素如何靶向特定的细胞类型进行裂解。最初假定膜脂质为细胞毒素受体候选物。但是，这些毒素的细胞类型特异性和物种依赖性靶向并不支持脂质作为唯一受体。现在对几种金黄色葡萄球菌细胞毒素的蛋白质受体的最新鉴定为观察到的向性提供了解释。这些发现也对研究金黄色葡萄球菌发病机理的动物模型的实施以及新型疗法的开发具有重要意义。

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