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首页> 外文期刊>Trends in Microbiology >Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1
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Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1

机译：全基因组序列比较显示霍乱弧菌O1的进化

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摘要

The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera.
机译：对以前和现在的霍乱大流行的霍乱弧菌菌株的全基因组序列分析表明，噬菌体CTX（特别是编码霍乱毒素B亚基的基因）的基因组变化和改变是V进化的主要特征。霍乱最近的研究已经揭示了这些细菌的遗传机制，通过这些机制可以从特定类型的菌株中产生霍乱弧菌的新变体。这些机制表明，随着时间的推移，某些菌株是由环境或人为因素选择的。通过了解霍乱弧菌种群历史和当前变化的机制和驱动力，可以预测这种变化的方向以及新变异的演变。这对战胜霍乱具有重要意义。

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