Enterovirus replication: go with the (counter)flow

Nchoutmboube Jules; Ford-Siltz Lauren A.; Belov George A.

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Enterovirus replication: go with the (counter)flow

机译：肠病毒复制：顺应（逆流）流程

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All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.

机译：所有（+）RNA病毒均在不同的膜结构域上复制;然而，它们如何诱导和维持其独特的脂质组成尚不清楚。最近的两项研究表明，肠病毒利用由OSBP1蛋白和PI4激酶驱动的PI4P-胆固醇交换周期，并且阻断动态脂质流动可抑制病毒复制。

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《Trends in Microbiology》 |2015年第4期|共2页
作者
Nchoutmboube Jules; Ford-Siltz Lauren A.; Belov George A.;
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原文格式 PDF
正文语种 eng
中图分类微生物学;
关键词
enterovirus replication organelles; cholesterol-PI4P exchange; lipid trafficking; oxysterol binding protein (OSBP); drug repurposing;

机译：肠道病毒复制细胞;胆固醇-PI4P交换;脂质运输;氧固醇结合蛋白（OSBP）;药物再利用;

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1. Enterovirus replication: go with the (counter)flow [J] . Nchoutmboube Jules, Ford-Siltz Lauren A., Belov George A. Trends in Microbiology . 2015,第4期

机译：肠病毒复制：顺应（逆流）流程
2. Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication [J] . Tao Wang, Bei Wang, He Huang, PLoS Pathogens . 2017,第10期

机译：肠病毒71蛋白酶2Apro和3Cpro通过不同的机制差异性地抑制细胞内质网相关的降解（ERAD）途径，肠病毒71劫持了ERAD组分p97以促进其复制
3. Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles [J] . Charlotte E. Melia, Hilde M. van der Schaar, Heyrhyoung Lyoo, Cell Reports . 2017,第3期

机译：逃逸宿主因子PI4KB抑制：缺乏复制细胞器的肠病毒基因组RNA复制。
4. Experimental Investigation of Interactions between a Normal Shock Wave and Various Counter Flows Using Counter-Driver Shock Tube [C] . T. Tamba, M. Kayumi, H. Kawasaki, AIAA aviation forum;AIAA fluid dynamics conference . 2016

机译：使用反驱动激波管对正常激波与各种逆流之间相互作用的实验研究
5. Defining the temporal roles of viral and cellular protein interactions during enterovirus replication. [D] . Cathcart, Andrea Lynn. 2013

机译：定义肠道病毒复制过程中病毒和细胞蛋白相互作用的暂时性作用。
6. Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication [O] . Corinna Benz, Frank Dondelinger, Paul G. McKean, -1

机译：通过离心逆流淘洗法对布鲁氏锥虫的细胞周期同步揭示了核和动塑料DNA复制的时机
7. Cell cycle synchronisation of Trypanosoma brucei by centrifugal counter-flow elutriation reveals the timing of nuclear and kinetoplast DNA replication [O] . Benz, Corinna, Dondelinger, Frank, McKean, Paul Gerard, 2017

机译：通过离心逆流淘洗法对布鲁氏锥虫的细胞周期同步揭示了核和动塑料DNA复制的时机

Enterovirus replication: go with the (counter)flow

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