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The continued pandemic threat posed by avian influenza viruses in Hong Kong

机译:香港禽流感病毒持续造成的大流行威胁

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In 1997, a highly pathogenic avian H5N 1 influenza virus was transmitted directly from live commercial poultry to humans in Hong Kong. Of the 18 people infected, six died. The molecular basis for the high virulence of this virus in mice was found toinvolve an amino acid change in the PB2 protein. To eliminate the source of the pathogenic virus, all birds in the Hong Kong markets were slaughtered. In 1999, another avian influenza virus of H9N2 subtype was transmitted to two children in Hong Kong. In2000-2002, H5N1 avian viruses reappeared in the poultry markets of Hong Kong, although they have not infected humans. Continued circulation of H5N1 and other avian viruses in Hong Kong raises the possibility of future human influenza outbreaks. Moreover, the acquisition of properties of human viruses by the avian viruses currently circulating in southeast China might result in a pandemic.
机译:1997年,高致病性禽类H5N 1流感病毒从活的商业家禽直接传播给香港的人类。在被感染的18人中,有6人死亡。发现这种病毒在小鼠中具有高毒力的分子基础涉及PB2蛋白中的氨基酸变化。为了消除病原病毒的来源,香港市场上的所有鸟类都被屠宰。 1999年,另一种H9N2亚型禽流感病毒在香港传播给两个孩子。 2000-2002年,H5N1禽流感病毒再次出现在香港的家禽市场,尽管它们尚未感染人类。 H5N1和其他禽流感病毒在香港的持续传播增加了未来人类流感爆发的可能性。此外,目前在中国东南部流行的禽流感病毒获取人类病毒的特性可能会导致大流行。

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