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首页> 外文期刊>Trends in Microbiology >Soil amoebae help to unravel fungal pathogenesis
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Soil amoebae help to unravel fungal pathogenesis

机译：土壤变形虫有助于阐明真菌的发病机理

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摘要

Cryptococcus neoformans is a facultative intracellular fungal pathogen that can cause life-threatening meningitis in immunocompromised patients. Its ecological niche is soil and the normal route of infection is inhalation of infectious particles. C.neoformans cells are encapsulated by a cell wall composed of polysaccharide, which protects the fungus from intracellular destruction by phagocytic cells. Legionella pneumophila was the first bacterial pathogen shown to multiply and persist in macrophages and amoebae. Amoebae and macrophages phagocytose particles into vacuoles and secrete lysosomal enzymes that digest the particles; the intracellular events after ingestion of L. pneumophila by amoebae and macrophages are similar.
机译：新型隐球菌是一种兼性的细胞内真菌病原体，可在免疫受损的患者中引起危及生命的脑膜炎。它的生态位是土壤，感染的正常途径是吸入感染性颗粒。新孢子虫细胞被由多糖组成的细胞壁包裹，该细胞壁保护真菌免受吞噬细胞的细胞内破坏。嗜肺军团菌是第一个在巨噬细胞和变形虫中繁殖并持续存在的细菌病原体。变形虫和巨噬细胞将吞噬酶颗粒吞噬成空泡，并分泌溶酶体酶来消化颗粒。变形虫和巨噬细胞摄入嗜肺乳杆菌后的细胞内事件相似。

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