The journey of tetanus and botulinum neurotoxins in neurons

Giovanna Lalli; Stephanie Bohnert; Katrin Deinhardt; Carole Verastegui; Giampietro Schiavo

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The journey of tetanus and botulinum neurotoxins in neurons

机译：破伤风和肉毒杆菌神经毒素在神经元中的旅程

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Anaerobic bacteria of the genus Clostridia are a major threat to human and animal health, being responsible for pathologies ranging from food poisoning to gas gangrene. In each of these, the production of sophisticated exotoxins is the main cause of disease. The most powerful clostridial toxins are tetanus and botulinum neurotoxins, the causative agents of tetanus and botulism. They are structurally organized into three domains endowed with distinct functions: high affinity binding to neurons, membrane translocation and specific cleavage of proteins controlling neuroexocytosis. Recent discoveries regarding the mechanism of membrane recruitment and sorting of these neurotoxins within neurons make them ideal tools to uncover essential aspects of neuronal physiology in health and disease.

机译：梭状芽胞杆菌属的厌氧细菌是对人类和动物健康的主要威胁，其病害范围从食物中毒到坏疽性气体。在每种情况下，复杂的外毒素的产生是疾病的主要原因。最有效的梭菌毒素是破伤风和肉毒杆菌神经毒素，它们是破伤风和肉毒杆菌中毒的病原体。它们在结构上分为具有不同功能的三个域：与神经元的高亲和力结合，膜移位和控制神经胞吐作用的蛋白质的特异性裂解。关于神经元内这些神经毒素的膜募集和分类机制的最新发现，使它们成为揭示健康和疾病中神经元生理学基本方面的理想工具。

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《Trends in Microbiology》 |2003年第9期|共7页
作者
Giovanna Lalli; Stephanie Bohnert; Katrin Deinhardt; Carole Verastegui; Giampietro Schiavo;
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1. The journey of tetanus and botulinum neurotoxins in neurons [J] . Giovanna Lalli, Stephanie Bohnert, Katrin Deinhardt, Trends in Microbiology . 2003,第9期

机译：破伤风和肉毒杆菌神经毒素在神经元中的旅程
2. Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons [J] . Ewa Bomba-Warczak, Jason?D. Vevea, Joel?M. Brittain, Cell Reports . 2016,第7期

机译：破伤风毒素和肉毒杆菌神经毒素A和D在中枢神经元中的神经元间转移和远端作用
3. Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons [J] . Beske Phillip H., Bradford Aaron B., Grynovicki Justin O., Toxicological sciences: An official journal of the Society of Toxicology . 2016,第2期

机译：肉毒杆菌和破伤风神经毒素诱导的人和啮齿动物神经元网络化培养中突触传递的阻断。
4. SNARE Based Peptide Linking as an Efficient Strategy to Retarget Botulinum Neurotoxin's Enzymatic Domain to Specific Neurons Using Diverse Neuropeptides as Targeting Domains [C] . Jason Arsenault, Enrico Ferrari, John OBrien American Peptide Symposium . 2011

机译：基于基于肽的肽作为使用不同的神经肽作为靶向结构域来将肉毒杆菌神经毒素的酶域与特异性神经元的有效策略联系起来
5. Analysis of type A botulinum neurotoxin expression in Clostridium botulinum. [D] . Dineen, Sean S. 2003

机译：分析肉毒梭菌中A型肉毒杆菌神经毒素的表达。
6. Exogenous mRNA encoding tetanus or botulinum neurotoxins expressed in Aplysia neurons. [O] . S Mochida, B Poulain, U Eisel, 2019

机译：编码破伤风或肉毒杆菌神经毒素的外源mRNA，在海Ap神经元中表达。
7. Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons [O] . Ewa Bomba-Warczak, Jason D. Vevea, Joel M. Brittain, 2016

机译：中枢神经元中破伤风毒素和肉毒神经毒素a和D的神经元转移和远端作用
8. Botulinum and Tetanus Neurotoxin Induced Blockage of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons. [R] . Beske, P. H., Bradford, A. B., Grynovicki, J. O., 2015

机译：肉毒杆菌和破伤风神经毒素诱导人和啮齿动物神经元网络培养中突触传递的阻断。

The journey of tetanus and botulinum neurotoxins in neurons

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