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首页> 外文期刊>Trends in Microbiology >Replication of human hepatitis delta virus: recent developments
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Replication of human hepatitis delta virus: recent developments

机译:人类肝炎三角洲病毒的复制:最新动态

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In a natural setting, hepatitis delta virus (HDV) is only found in patients that are also infected with hepatitis B virus (HBV). In hepatocytes infected with these two viruses, HDV RNA genomes are assembled using the envelope proteins of HBV. Since 1986, we have known that HDV has a small single-stranded RNA genome with a unique circular conformation that is replicated using a host RNA polymerase These and other features make HDV and its replication unique, at least among agents that infect animals. This mini-review focuses on advances gained over the last 2-3 years, together with an evaluation of HDV questions that are either unsolved or not yet solved satisfactorily.
机译:在自然环境中,仅在也感染了乙型肝炎病毒(HBV)的患者中发现了丙型肝炎三角洲病毒(HDV)。在感染了这两种病毒的肝细胞中,使用HBV的包膜蛋白组装HDV RNA基因组。自1986年以来,我们就知道HDV具有一个很小的单链RNA基因组,具有独特的环状构象,可以使用宿主RNA聚合酶复制这些特征和其他特征,至少在感染动物的媒介中,HDV及其复制是独特的。这份小型复习集中于过去2-3年中取得的进展,以及对尚未解决或尚未令人满意地解决的HDV问题的评估。

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