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Virus yoga: the role of flexibility in virus host cell recognition

机译:病毒瑜伽:灵活性在病毒宿主细胞识别中的作用

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摘要

Viral capsid proteins and their receptors interact in the context of the virus particle and the plasma membrane to initiate virus entry. For the non-enveloped adenovirus, flexibility in its receptor-binding protein permits receptor binding to occur while avoiding steric constraints that are imposed by the large virus capsids and the cell surface and might also facilitate interaction with secondary receptors. Such flexibility in capsid protein structure is shared by the structurally related reovirus. The presence of hinges in the virus attachment molecule suggests that proper orientation of the receptor-binding site for viral adhesion depends on the flexibility of the receptor or viral ligand, especially for viruses that require the use of multiple receptors.
机译:病毒衣壳蛋白及其受体在病毒颗粒和质膜的环境中相互作用,启动病毒进入。对于非包膜的腺病毒,其受体结合蛋白的柔韧性允许发生受体结合,同时避免了由大病毒衣壳和细胞表面施加的空间限制,并且还可能促进与次级受体的相互作用。衣壳蛋白结构的这种灵活性被结构相关的呼肠孤病毒所共有。病毒附着分子中铰链的存在表明,用于病毒粘附的受体结合位点的正确方向取决于受体或病毒配体的柔韧性,特别是对于需要使用多种受体的病毒。

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