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首页> 外文期刊>Trends in Microbiology >Exploring cargo transport mechanics in the type IV secretion systems
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Exploring cargo transport mechanics in the type IV secretion systems

机译：探索IV型分泌系统中的货物运输机制

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Type IV secretion systems (T4SSs) are used by various bacteria to deliver protein and DNA molecules to a wide range of target cells. These include systems that are directly involved in pathogenesis, such as the secretion of pertussis toxin by Bordetella pertussis into human cells and the delivery of single-stranded DNA (ssDNA) into plants by Agrobacterium. These complex systems are composed of proteins that span the bacterial cytoplasm. The Agrobacterium T4SS is composed of 12 virulence proteins and delivers its transferred ssDNA and several virulence protein substrates to a variety of eukaryotic cells. Recent studies on the Agrobacterium T4SS have revealed new information on the localization and structure of its proteins in the bacteria, the biochemical properties of its transport signal, the route of a DNA substrate through the secretion system, and the initial point of contact of the system with its host. These findings have expanded our knowledge and understanding of the still mostly obscure structure and function of the T4SSs.
机译：各种细菌都使用IV型分泌系统（T4SSs）将蛋白质和DNA分子输送到多种靶细胞。这些包括直接参与发病机制的系统，例如百日咳博德特氏菌将百日咳毒素分泌到人细胞中，农杆菌将单链DNA（ssDNA）输送到植物中。这些复杂的系统由跨细菌细胞质的蛋白质组成。农杆菌T4SS由12种毒力蛋白组成，并将其转移的ssDNA和几种毒力蛋白底物传递给各种真核细胞。农杆菌T4SS的最新研究揭示了有关其蛋白质在细菌中的定位和结构，其转运信号的生化特性，DNA底物通过分泌系统的途径以及该系统接触的起始点的新信息。与它的主人。这些发现扩大了我们对T4SS仍然最晦涩的结构和功能的知识和理解。

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