Intimin and the host cell - is it bound to end in Tir(s)?

Gad Frankel; Alan D. Phillips; Luiz R. Trabulsi; Stuart Knutton; Gordon Dougan; Stephen Matthew

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Intimin and the host cell - is it bound to end in Tir(s)?

机译：内膜蛋白和宿主细胞-它必然以Tir终止吗？

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Intimate bacterial adhesion to the intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli. Two bacterial protein partners involved in this intimate association have been identified, intimin and Tir. Some key remaining questions include whether intimin specifically interacts with one or more host-cell-encoded molecules and whether these contacts are a prerequisite for the subsequent intimate intimin-Tir association. Recent data support the hypothesis that the formation of a stable intimin-Tir relationship is the consequence of intimin protein interactions involving both host and bacterial components.

机译：细菌粘附到肠上皮是几种人类和动物肠道病原体（包括肠致病性和肠出血性大肠杆菌）共有的致病机制。已经确定了参与这种密切联系的两个细菌蛋白伴侣，即intimin和Tir。剩下的一些关键问题包括：intimin是否与一个或多个宿主细胞编码的分子特异性相互作用，以及这些接触是否是随后的紧密intimin-Tir关联的前提。最近的数据支持以下假设：稳定的intimin-Tir关系的形成是涉及宿主和细菌成分的intimin蛋白相互作用的结果。

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《Trends in Microbiology》 |2001年第5期|共5页
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Gad Frankel; Alan D. Phillips; Luiz R. Trabulsi; Stuart Knutton; Gordon Dougan; Stephen Matthew;
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1. Intimin and the host cell - is it bound to end in Tir(s)? [J] . Gad Frankel, Alan D. Phillips, Luiz R. Trabulsi, Trends in Microbiology . 2001,第5期

机译：内膜蛋白和宿主细胞-它必然以Tir终止吗？
2. Talin, a host cell protein, interacts directly within the translocated intimin receptor, Tir, of enteropathogenic Escherichia coli, and is essential for pedestal formation [J] . Vlademir V. Cantarelli, Akira Takahashi, Itaru Yanagihara, Cellular microbiology . 2001,第11期

机译：Talin是一种宿主细胞蛋白，可直接在肠致病性大肠杆菌的易位内膜受体Tir中相互作用，并且对形成基座至关重要
3. The Tir-binding region of enterohaemorrhagic Escherichia coli intimin is sufficient to trigger actin condensation after bacterial-induced host cell signalling. [J] . Liu H, Magoun L, Luperchio S, Molecular Microbiology . 1999,第1期

机译：肠出血性大肠杆菌内膜蛋白的Tir结合区足以在细菌诱导的宿主细胞发出信号后触发肌动蛋白凝集。
4. Real-time monitoring of Ca²⁺ concentration in pancreatic beta cells by a microfluidic device integrated with Total Internal Reflection (TIR)-based chip [C] . Kitazawa Y., Yokokawa R., Terao K., 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems . 2011

机译：集成基于全内反射（TIR）的微流控设备实时监测胰岛β细胞中Ca ^{2 + 的浓度}
5. An anti-pyruvate kinase monoclonal antibody and translocated intimin receptor (tir) for specific detection of listeria species and shiga-toxigenic escherichia coli. [D] . Dikshit, Titiksha. 2013

机译：抗丙酮酸激酶单克隆抗体和易位intimin受体（tir），用于特异性检测李斯特菌和志贺毒素毒素大肠埃希氏菌。
6. The Established Intimin Receptor Tir and the Putative Eucaryotic Intimin Receptors Nucleolin and β1 Integrin Localize at or near the Site of Enterohemorrhagic Escherichia coli O157:H7 Adherence to Enterocytes In Vivo [O] . James F. Sinclair, Evelyn A. Dean-Nystrom, Alison D. OBrien 2006

机译：建立的Intimin受体Tir和推定的真核Intimin受体Nucleolin和β1整联蛋白位于肠出血性大肠杆菌O157：H7或与肠道细胞粘附的部位附近
7. The Tir-binding region of enterohaemorrhagic Escherichia coli intimin is sufficient to trigger actin condensation after bacterial-induced host cell signalling [O] . Liu, Hui, Magoun, Loranne, Luperchio, Steven A., 1999

机译：肠出血性大肠杆菌intimin的Tir结合区足以在细菌诱导的宿主细胞信号传导后触发肌动蛋白浓缩

Intimin and the host cell - is it bound to end in Tir(s)?

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