Discovering the sweeping power of point mutations using a GIRAFF

Evgeni V. Sokurenko

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Discovering the sweeping power of point mutations using a GIRAFF

机译：使用GIRAFFE发现点突变的强大功能

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In pathogenic bacteria, point and other simple mutations can provide a strong selective advantage during the course of a single infection. Our understanding of the importance of these randomly occurring mutations has been hampered by a lack of technologies allowing mutation scanning on a genomic scale.Here, a novel technology is described that makes it possible to scan, in a single Southern blot experiment, the sequence identity of genomic regions with a combined length of hundreds of kilobases.

机译：在病原细菌中，点和其他简单突变可在单次感染过程中提供强大的选择性优势。我们对这些随机发生的突变的重要性的理解因缺乏允许在基因组规模上进行突变扫描的技术而受到阻碍。在此，我们描述了一种新颖的技术，该技术使得可以在单个Southern blot实验中扫描序列同一性总长度达数百千碱基的基因组区域。

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《Trends in Microbiology》 |2001年第11期|共4页
作者
Evgeni V. Sokurenko;
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Discovering the sweeping power of point mutations using a GIRAFF

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