C3stau, a new member of the family of C3-like ADP-ribosyltransferases

Christian Wilde; Gursharan S. Chhatwal; Klaus Aktories

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C3stau, a new member of the family of C3-like ADP-ribosyltransferases

机译：C3stau，C3样ADP-核糖基转移酶家族的新成员

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C3-like ADP-ribosyltransferases, which are produced by Clostridium botulinum, Clostridium limosum, Bacillus cereus and Staphylococcus aureus, are exoenzymes lacking a translocation unit. These enzymes specifically inactivate Rho GTPases in host target cells. Recently, a novel C3-like transferase from S. aureus with new properties was identified, raising questions regarding its function. As Rho GTPases are master regulators of several eukaryotic signal processes and S. aureus can invade eukaryotic cells, C3 might play a role as a virulence factor.

机译：由肉毒梭菌，利什曼梭菌，蜡状芽孢杆菌和金黄色葡萄球菌产生的C3样ADP-核糖基转移酶是缺乏易位单位的外切酶。这些酶特异性地灭活宿主靶细胞中的Rho GTPases。最近，鉴定了具有新特性的来自金黄色葡萄球菌的新型C3样转移酶，引起了有关其功能的疑问。由于Rho GTPases是几种真核信号过程的主要调节剂，而金黄色葡萄球菌可以侵染真核细胞，因此C3可能起毒力因子的作用。

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《Trends in Microbiology》 |2002年第1期|共3页
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Christian Wilde; Gursharan S. Chhatwal; Klaus Aktories;
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1. C3stau, a new member of the family of C3-like ADP-ribosyltransferases [J] . Christian Wilde, Gursharan S. Chhatwal, Klaus Aktories Trends in Microbiology . 2002,第1期

机译：C3stau，C3样ADP-核糖基转移酶家族的新成员
2. Localization of the C3-Like ADP-Ribosyltransferase from Staphylococcus aureus during Bacterial Invasion of Mammalian Cells [J] . Gabriella Molinari, Manfred Rohde, Christian Wilde, Infection and immunity . 2006,第6期

机译：金黄色葡萄球菌细菌侵袭过程中来自金黄色葡萄球菌的C3-like ADP-核糖基转移酶的定位
3. Rho-modifying C3-like ADP-ribosyltransferases [J] . K. Aktories, C. Wilde, M. Vogelsgesang Reviews of physiology, biochemistry and pharmacology. . 2004,第0期

机译：Rho修饰的C3样ADP-核糖基转移酶
4. Homology modeling and molecular dynamics studies of a novel C3-like ADP-ribosyltransferase [C] . Jing-fa Xiao, Ze-sheng Li, Chia-chung Sun 第二届全国分子模拟与信息技术软件应用研讨会暨第四届创腾科技用户大会 . 2005

机译：新型C3样ADP-核糖基转移酶的同源性建模和分子动力学研究
5. An examination of the role of SpyA, an ADP-ribosyltransferase, in Streptococcus pyogenes pathogenesis. [D] . Hoff, Jessica S. 2010

机译：检查化脓性链球菌发病机理中的SpyA（一种ADP-核糖基转移酶）的作用。
6. SpyA a C3-Like ADP-Ribosyltransferase Contributes to Virulence in a Mouse Subcutaneous Model of Streptococcus pyogenes Infection [O] . Jessica S. Hoff, Mark DeWald, Steve L. Moseley, 2011

机译：SpyAC3样的ADP-核糖基转移酶有助于化脓性链球菌感染的小鼠皮下模型中的毒力。
7. SpyA, a C3-Like ADP-Ribosyltransferase, Contributes to Virulence in a Mouse Subcutaneous Model of Streptococcus pyogenes Infection ▿ † ‡ [O] . Hoff, Jessica S., DeWald, Mark, Moseley, Steve L., 2011

机译：SpyA，一种类似于C3的ADP-核糖基转移酶，有助于化脓性链球菌感染的小鼠皮下模型中的毒力。 ▿ † ‡

C3stau, a new member of the family of C3-like ADP-ribosyltransferases

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