Synonymous Virus Genome Recocing as a Tool to Impact Viral Fitness

Angel Martinez Miguel; Jordan-Paiz Ana; Franco Sandra; Nevot Maria

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Synonymous Virus Genome Recocing as a Tool to Impact Viral Fitness

机译：同义词病毒基因组重新识别为影响病毒适应性的工具

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Synthetic genome recoding is a novel method of generating viruses with altered phenotypes, whereby many synonymous mutations are introduced into the protein coding region of the virus genome without altering the encoded proteins. Virus genome recoding with large numbers of slightly deleterious mutations has produced attenuated forms of several RNA viruses. Virus genome recoding can also aid in investigating virus interactions with innate immune responses, identifying functional virus genome structures, strategically ameliorating cis-inhibitory signaling sequences related to complex viral functions, to unravel the relevance of codon usage for the temporal regulation of viral gene expression and improving our knowledge of virus mutational robustness and adaptability. The present review discusses the impacts of synonymous genome recoding with regard to expanding our comprehension of virus biology, and the development of new and better therapeutic strategies.

机译：合成基因组重新编码是一种生成具有改变表型的病毒的新方法，其中许多同义突变被引入到病毒基因组的蛋白质编码区域，而不会改变编码的蛋白质。带有大量轻微有害突变的病毒基因组编码已产生几种RNA病毒的减毒形式。病毒基因组重新编码还可帮助调查病毒与先天免疫应答的相互作用，鉴定病毒基因组结构，策略性改善与复杂病毒功能相关的顺式抑制性信号转导序列，以揭示密码子使用与病毒基因表达的暂时调控和相关性的相关性。提高我们对病毒突变的鲁棒性和适应性的了解。本综述讨论同义基因组重新编码对扩大我们对病毒生物学的理解以及开发新的更好治疗策略的影响。

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《Trends in Microbiology》 |2016年第2期|共14页
作者
Angel Martinez Miguel; Jordan-Paiz Ana; Franco Sandra; Nevot Maria;
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1. Synonymous Virus Genome Recocing as a Tool to Impact Viral Fitness [J] . Angel Martinez Miguel, Jordan-Paiz Ana, Franco Sandra, Trends in Microbiology . 2016,第2期

机译：同义词病毒基因组重新识别为影响病毒适应性的工具
2. Influence of genome-scale RNA structure disruption on the replication of murine norovirus—similar replication kinetics in cell culture but attenuation of viral fitness in vivo [J] . Nora McFadden, Armando Arias, Inga Dry, Nucleic Acids Research . 2013,第12期

机译：基因组规模的RNA结构破坏对鼠诺如病毒复制的影响-细胞培养中相似的复制动力学，但体内病毒适应性减弱
3. Influence of genome-scale RNA structure disruption on the replication of murine norovirus—similar replication kinetics in cell culture but attenuation of viral fitness in vivo [J] . Armando Arias, Dalan Bailey, David J. Evans, Nucleic acids research . 2013,第12期

机译：基因组规模的RNA结构破坏对鼠诺如病毒复制的影响-细胞培养中相似的复制动力学，但体内病毒适应性减弱
4. An Analysis of k-Mer Frequency Features with Machine Learning Models for Viral Subtyping of Polyomavirus and HIV-1 Genomes [C] . V. E. Machaca Future Technologies Conference . 2021

机译：k-mer频率特征分析，具有多元瘤菌和HIV-1基因组病毒亚型的机器学习模型
5. The impact of human immunodeficiency virus type 1 entry on drug development, drug resistance and viral fitness. [D] . Marozsan, Andre John. 2003

机译：1型人类免疫缺陷病毒进入对药物开发，耐药性和病毒适应性的影响。
6. The Impacts of Antivirals on the Coronavirus Genome Structure and Subsequent Pathogenicity Virus Fitness and Antiviral Design [O] . Ching-Hung Lin, Cheng-Yao Yang, Shan-Chia Ou, 2020

机译：抗病毒药对冠状病毒基因组结构和随后致病性病毒健身和抗病毒设计的影响
7. The Impacts of Antivirals on the Coronavirus Genome Structure and Subsequent Pathogenicity, Virus Fitness and Antiviral Design [O] . Ching-Hung Lin, Cheng-Yao Yang, Shan-Chia Ou, 2020

机译：抗病毒药对冠状病毒基因组结构和随后致病性，病毒健身和抗病毒设计的影响

Synonymous Virus Genome Recocing as a Tool to Impact Viral Fitness

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