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首页> 外文期刊>Trends in Microbiology >Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria
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Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria

机译：表面暴露的脂蛋白：革兰氏阴性细菌中的新兴分泌现象。

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摘要

Bacterial lipoproteins are hydrophilic proteins that are anchored to a cell membrane by N-terminally linked fatty acids. It is widely believed that nearly all lipoproteins produced by Gram-negative bacteria are either retained in the inner membrane (IM) or transferred to the inner leaflet of the outer membrane (OM). Lipoproteins that are exposed on the cell surface have also been reported but are generally considered to be rare. Results from a variety of recent studies, however, now suggest that the prevalence of surface-exposed lipoproteins has been underestimated. In this review we describe the evidence that the surface exposure of lipoproteins in Gram-negative bacteria is a widespread phenomenon and discuss possible mechanisms by which these proteins might be transported across the OM.
机译：细菌脂蛋白是亲水性蛋白，通过N端连接的脂肪酸锚定在细胞膜上。普遍认为，革兰氏阴性细菌产生的几乎所有脂蛋白都保留在内膜（IM）中或转移到外膜的内小叶（OM）中。也已经报道了暴露在细胞表面的脂蛋白，但通常认为是罕见的。然而，来自各种近期研究的结果表明，低估了表面暴露的脂蛋白的患病率。在这篇综述中，我们描述了革兰氏阴性细菌中脂蛋白表面暴露是一种普遍现象的证据，并讨论了这些蛋白可能通过OM转运的可能机制。

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