The EGFR as a target for viral oncoproteins

William E. Miller; Nancy Raab-Traub

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The EGFR as a target for viral oncoproteins

机译：EGFR作为病毒癌蛋白的靶标

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The epidermal growth factor receptor (EGFR) is a potent stimulator of the mitogen-activated protein kinase (MAPK) signaling pathway. Chronic stimulation of the EGFR and of multiple steps in the MAPK signaling pathway is involved in the development of cancer. Several tumor viruses encode proteins that induce EGFR expression or stimulate EGFR-mediated signaling and are thus likely to play an important role in the transformation of virus-infected cells.

机译：表皮生长因子受体（EGFR）是促有丝分裂原活化蛋白激酶（MAPK）信号通路的有效刺激剂。 EGFR的慢性刺激以及MAPK信号通路中的多个步骤都参与了癌症的发展。几种肿瘤病毒编码诱导EGFR表达或刺激EGFR介导的信号传导的蛋白质，因此可能在病毒感染细胞的转化中起重要作用。

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《Trends in Microbiology》 |1999年第11期|共6页
作者
William E. Miller; Nancy Raab-Traub;
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正文语种 eng
中图分类微生物学;
关键词
the epidermal growth factor receptor; the mitogen-activated protein kinases; proteins;

机译：表皮生长因子受体;促分裂原活化的蛋白激酶;蛋白质;

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专利

1. The EGFR as a target for viral oncoproteins [J] . William E. Miller, Nancy Raab-Traub Trends in Microbiology . 1999,第11期

机译：EGFR作为病毒癌蛋白的靶标
2. E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer [J] . Morgan Ethan L., Scarth James A., Patterson Molly R., Cell death and differentiation . 2021,第5期

机译：E6介导的JNK活化驱动EGFR信号传导，促进宫颈癌中的增殖和病毒癌蛋白表达
3. Is viral E6 oncoprotein a viable target? A critical analysis in the context of cervical cancer [J] . Kumar Avinash, Rathi Ekta, Hariharapura Raghu Chandrashekar, Medicinal research reviews . 2020,第5期

机译：病毒e6癌蛋白是一种可行的目标吗？宫颈癌背景下的关键分析
4. Development of an Antibody-Drug Conjugate Targeting the MUC1-C Oncoprotein on Human Cancer Cells [C] . Govindaswamy Panchamoorthy, Gaining Jin, Deepak Raina, Protein Engineering Summit. . 2018

机译：靶向人癌细胞上的MUC1-C癌蛋白的抗体 - 药物缀合物的研制
5. Deregulation of signal transduction pathways by the latent viral oncoproteins of Kaposi's sarcoma herpesvirus (KSHV/HHV-8). [D] . Bubman, Darya. 2007

机译：卡波西氏肉瘤疱疹病毒（KSHV / HHV-8）的潜伏病毒癌蛋白对信号转导途径的失调。
6. E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer [O] . Ethan L. Morgan, James A. Scarth, Molly R. Patterson, 2021

机译：E6介导的JNK活化驱动EGFR信号传导促进宫颈癌中的增殖和病毒癌蛋白表达
7. Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7 [O] . Kwun Hyun Jin, Shuda Masahiro, Feng Huichen, 2013

机译：默克尔细胞多瘤病毒小T抗原通过靶向细胞泛素连接酶SCFFbw7控制病毒复制和癌蛋白表达。

The EGFR as a target for viral oncoproteins

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