Microbial superantigens: from structure to function

Anastassios C. Papageorgiou; K. Ravi Acharya

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Microbial superantigens: from structure to function

机译：微生物超抗原：从结构到功能

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Superantigens are highly potent immune stimulators with a unique ability to interact simultaneously with MHC class II molecules and T cell receptors, forming a trimolecular complex that induces profound T-cell proliferation and massive cytokine production. Recent structural studies have provided a wealth of information regarding these complex interactions, and it is now emerging that, despite their common 3-D architecture, superantigens are able to crosslink MHC class II molecules and T cell receptors in a variety of ways.

机译：超抗原是高效的免疫刺激剂，具有与MHC II类分子和T细胞受体同时相互作用的独特能力，形成三分子复合物，可诱导大量T细胞增殖和大量细胞因子产生。最近的结构研究已经提供了有关这些复杂相互作用的大量信息，并且尽管它们具有常见的3-D结构，超抗原仍能够以多种方式交联II类MHC分子和T细胞受体。

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《Trends in Microbiology》 |2000年第8期|共7页
作者
Anastassios C. Papageorgiou; K. Ravi Acharya;
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正文语种 eng
中图分类微生物学;
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1. The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens. [J] . B C Cole, K L Knudtson, A Oliphant, The Journal of Experomental Medicine . 1996,第3期

机译：关节炎支原体超抗原（MAM）的序列：功能域的鉴定以及与微生物超抗原和植物凝集素有丝分裂原的比较。
2. Microbial superantigens: from structure to function [J] . Anastassios C. Papageorgiou, K. Ravi Acharya Trends in Microbiology . 2000,第8期

机译：微生物超抗原：从结构到功能
3. Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 angstrom resolution: Implications for superantigen recognition by MHC class II molecules and T-cell receptors [J] . Papageorgiou AC., Acharya KR., Tranter HS. Journal of Molecular Biology . 1998,第1期

机译：微生物超抗原葡萄球菌肠毒素B的晶体结构，分辨率为1.5埃：MHC II类分子和T细胞受体对超抗原识别的意义
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6. The sequence of the Mycoplasma arthritidis superantigen MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens [O] . 1996

机译：关节炎支原体超抗原的序列MAM：功能域的鉴定以及与微生物超抗原和植物凝集素有丝分裂原的比较
7. The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens [O] . 1996

机译：关节炎支原体超抗原的序列，MAM：功能域的鉴定以及与微生物超抗原和植物凝集素促细胞分裂素的比较

Microbial superantigens: from structure to function

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