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The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions

机译:葡萄球菌转铁蛋白受体:具有新型功能的糖酵解酶

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摘要

To obtain iron from the host for growth, staphylococci have evolved sophisticated iron-scavenging systems including siderophores and a cell surface receptor for transferrin, the mammalian iron-transporting glycoprotein. The staphylococcal transferrin receptor has been identified as a member of a newly emerging family of multifunctional, cell-surface-associated glyceraldehyde-3-phosphate dehydrogenases, which not only retain their glycolytic enzyme activities but also bind diverse human serum proteins and possess NAD-ribosylating activity. These multiple functions suggest a potential contribution to virulence far beyond iron acquisition.
机译:为了从宿主生长中获得铁,葡萄球菌已经进化出了复杂的除铁系统,包括铁载体和运铁蛋白(哺乳动物的铁转运糖蛋白)的细胞表面受体。葡萄球菌转铁蛋白受体已被确定为一个新兴的多功能的细胞表面相关的甘油醛-3-磷酸脱氢酶家族的成员,该酶不仅保留其糖酵解酶活性,而且结合多种人血清蛋白并具有NAD-核糖基化作用活动。这些多重功能表明,除了铁的获得之外,对毒力的潜在贡献也很大。

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