Is there a role for CEA in innate immunity in the colon?

Sten Hammarstrom; Vladimir Baranov

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Is there a role for CEA in innate immunity in the colon?

机译：CEA在结肠固有免疫中是否起作用？

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Carcinoembryonic antigen (CEA) is a well known tumor marker associated with the progression of colorectal tumors. The CEA family of glycoproteins has been fully characterized and the function of some of its members is now beginning to be understood. Here, we advance the hypothesis that, rather than functioning in cell adhesion as has been suggested previously, CEA plays a role in protecting the colonic mucosa from microbial invasion. This hypothesis is based on new microscopic, molecular, phylogenetic and microbiological evidence.

机译：癌胚抗原（CEA）是与大肠肿瘤进展相关的众所周知的肿瘤标志物。 CEA糖蛋白家族已得到充分表征，其某些成员的功能现已开始被理解。在这里，我们提出一个假设，即CEA并非在细胞粘附中起作用，而是在保护结肠粘膜免受微生物侵袭中发挥作用。该假设基于新的微观，分子，系统发育和微生物学证据。

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《Trends in Microbiology》 |2001年第3期|共7页
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Sten Hammarstrom; Vladimir Baranov;
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中图分类微生物学;
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Is there a role for CEA in innate immunity in the colon?

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