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首页> 外文期刊>Tropical Medicine and International Health: TM and IH >Does radical cure of asymptomatic Plasmodium falciparum place adults in endemic areas at increased risk of recurrent symptomatic malaria?
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Does radical cure of asymptomatic Plasmodium falciparum place adults in endemic areas at increased risk of recurrent symptomatic malaria?

机译：彻底治愈无症状的恶性疟原虫是否会使成年人处于流行区域，从而增加复发性症状性疟疾的风险？

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摘要

A cohort of 197 adults in Kassena-Nankana District (northern Ghana) was radically cured of malaria parasites to study subsequent incidence of malaria infection. During the following 20 weeks of the malaria transmission season, 49% experienced clinical attacks associated with Plasmodium falciparum parasitaemia. In a group of 202 adults identically followed-up 1 year later without being treated, only 38% experienced such episodes (log-rank test for equality of survivor functions, P=0.035). Clinical attacks in radically cured individuals presented with lower parasite densities but more symptoms. Randomized studies are needed to test the hypothesis that radical cure of P. falciparum enhances the risk and severity of subsequent clinical malaria attacks.
机译：在加纳北部的卡塞纳-纳纳卡纳区（Kassena-Nankana District），有197名成年人被彻底治愈了疟原虫，以研究随后的疟疾感染发生率。在接下来的20周疟疾传播季节中，有49％的人经历了与恶性疟原虫寄生虫血症相关的临床发作。在一组202名成年人中，他们在一年后未经治疗而接受了同样的随访，只有38％的人经历过此类发作（幸存者功能均等性的对数检验，P = 0.035）。彻底治愈的个体的临床发作具有较低的寄生虫密度，但症状却更多。需要进行随机研究来检验以下假设：恶性疟原虫的彻底治愈会增加随后的临床疟疾发作的风险和严重性。

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