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首页> 外文期刊>Tropical Medicine and International Health: TM and IH >Utility of measuring serum levels of anti-PGL-I antibody, neopterin and C-reactive protein in monitoring leprosy patients during multi-drug treatment and reactions.
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Utility of measuring serum levels of anti-PGL-I antibody, neopterin and C-reactive protein in monitoring leprosy patients during multi-drug treatment and reactions.

机译：测量抗PGL-1抗体，新蝶呤和C反应蛋白的血清水平在监测麻风病人的多种药物治疗和反应中的实用性。

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OBJECTIVE: To verify the validity of measuring the levels of Mycobacterium leprae-specific anti-phenolic glycolipid (PGL)-I antibody, neopterin, a product of activated macrophages, and C-reactive protein (CRP), an acute phase protein, in serial serum samples from patients for monitoring the leprosy spectrum and reactions during the course of multi-drug treatment (MDT). METHODS: Twenty-five untreated leprosy patients, 15 multi-bacillary (MB) and 10 paucibacillary (PB), participated. Eight patients developed reversal reaction and five developed erythema nodosum leprosum (ENL) during follow-up. The bacterial index (BI) in slit-skin smears was determined at diagnosis and blood samples collected by venipuncture at diagnosis and after 2, 4, 6 and 12 months of MDT. PGL-I antibody and neopterin were measured by enzyme-linked immunosorbent assay, whereas the CRP levels were measured by the latex agglutination method. RESULTS: The levels of PGL-I antibodies and neopterin were higher in the sera of MB than PB patients, which correlated with the patients' BI. The serum levels of CRP did not differ significantly between the MB and PB patients. The serum levels of PGL-I and neopterin were no higher in reactional patients than non-reactional patients prone to such reactions. However, ENL patients had higher serum CRP levels than non-reactional MB patients. The serum PGL-I antibody levels declined significantly during MDT, in contrast to neopterin and CRP levels. CONCLUSION: Measuring the serum levels of PGL-I antibodies and neopterin appeared to be useful in distinguishing MB from PB patients, whereas monitoring the levels of PGL-I antibodies appeared to be useful in monitoring MB patients on MDT. Measuring serum CRP, although not useful in monitoring the patients, has limited significance in detecting ENL reactional patients.
机译：目的：验证串行测量麻风分枝杆菌特异性抗酚糖脂（PGL）-I抗体，新蝶呤（一种激活的巨噬细胞的产物）和一种C相反应蛋白（CRP）（一种急性期蛋白）的水平的有效性从患者的血清样品中监测多药治疗（MDT）过程中的麻风病谱和反应。方法：25例未经治疗的麻风病患者，其中15例为多细菌性（MB）和10例脓疱性（PB）。在随访过程中，八名患者发生了逆反应，五名患者出现了结节性红斑麻风病（ENL）。在诊断时确定裂口皮肤涂片中的细菌指数（BI），在诊断时以及MDT的2、4、6和12个月后通过静脉穿刺收集血液样本。通过酶联免疫吸附测定法测定PGL-1抗体和新蝶呤，而通过乳胶凝集法测定CRP水平。结果：MB患者血清中的PGL-1抗体和新蝶呤水平高于PB患者，这与患者的BI有关。 MB和PB患者之间的CRP血清水平无显着差异。反应性患者的PGL-1和新蝶呤的血清水平不高于容易发生这种反应的非反应性患者。但是，ENL患者的血清CRP水平高于非反应性MB患者。与新蝶呤和CRP水平相比，MDT期间血清PGL-1抗体水平显着下降。结论：测量PGL-1抗体和新蝶呤的血清水平似乎有助于区分MB和PB患者，而监测PGL-1抗体水平似乎对监测MDT的MB患者有用。血清CRP的测定尽管无助于监测患者，但对检测ENL反应性患者的意义有限。

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