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HIV-1 and the host cell: an intimate association

机译:HIV-1与宿主细胞:密切的联系

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As obligate parasites, viruses must rely heavily on host cell machinery to replicate and spread. Because of their relatively limited coding capacity, viruses with small genomes are particularly dependent on cellular factors. In the case of retroviruses, interactions with host cell machinery are evident at virtually every step in the replication cycle, from binding and entry to particle release. Recent studies on human immunodeficiency virus type 1 (HIV-1) have illustrated the extent to which retroviruses have evolved to usurp host cell processes and counter intracellular antiviral defenses. This review highlights the relationship between HIV-1 and host factors, and focuses on new developments in our understanding of how HIV-1 has evolved to use cellular machinery and avoid antiviral restriction.
机译:作为专性寄生虫,病毒必须严重依赖宿主细胞机制来复制和传播。由于其相对有限的编码能力,具有小基因组的病毒特别依赖于细胞因子。在逆转录病毒的情况下,在复制周期的几乎每个步骤中,从结合和进入到粒子释放,与宿主细胞机制的相互作用都是显而易见的。最近对1型人类免疫缺陷病毒(HIV-1)的研究表明,逆转录病毒已发展到侵占宿主细胞进程和对抗细胞内抗病毒防御能力的程度。这篇综述强调了HIV-1与宿主因素之间的关系,并着重于我们对HIV-1如何进化为使用细胞机制并避免抗病毒限制的了解中的新进展。

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