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首页> 外文期刊>Tropical Medicine and International Health: TM and IH >Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre.
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Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre.

机译：来自一家大型巴西中心的献血者的弓形虫感染与嗜酸性粒细胞增多和总IgE有关。

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摘要

OBJECTIVE: To investigate the association between Toxocara canis infection and total IgE levels and eosinophilia in blood donors from a large Brazilian city. METHODS: Two hundred and sixty-eight blood donors from a government blood bank were tested. No helminth infection was diagnosed by parasitological stool examination. Total IgE levels and T. canis infection status were determined by ELISA. Eosinophil levels were determined using an automatic blood cell counter. RESULTS: Toxocara canis IgG antibodies were found in 124 (46.3%); 102 (38.0%) had eosinophilia >/=4% and 29 (10.8%) had eosinophilia >/=10%, respectively; 140 (52.2%) individuals had total IgE antibodies above the cut-off levels. Both total IgE and eosinophil levels >/=10% were positively associated with the infection. CONCLUSION: This study revealed a high prevalence of T. canis infection in blood donors, highlighting the need for screening for this infection. It also demonstrated that this population otherwise healthy has higher levels of blood eosinophils and total IgE and that both parameters are associated with T. canis infection.
机译：目的：探讨巴西某大城市献血者中犬弓形虫感染与总IgE水平和嗜酸性粒细胞增多之间的关系。方法：测试了来自政府血库的168个献血者。寄生虫粪便检查未诊断出蠕虫感染。通过ELISA确定总的IgE水平和犬圆弧菌感染状态。使用自动血细胞计数器测定嗜酸性粒细胞水平。结果：弓形虫弓形虫IgG抗体被发现124（46.3％）;嗜酸性粒细胞增多> / = 4％的有102（38.0％），嗜酸性粒细胞增多≥== 10％的29（10.8％）; 140（52.2％）个人的总IgE抗体高于临界水平。总IgE和嗜酸性粒细胞水平≥10％均与感染呈正相关。结论：这项研究揭示了献血犬中T. canis感染的高患病率，突出了对这种感染进行筛查的必要性。这也表明该原本健康的人群血液中的嗜酸性粒细胞和总IgE水平较高，并且这两个参数均与犬T. canis感染有关。

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