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首页> 外文期刊>Tropical Animal Health and Production >Anthelminthic activity of acetone extract and fractions of Vernonia amygdalina against Haemonchus contortus eggs and larvae
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Anthelminthic activity of acetone extract and fractions of Vernonia amygdalina against Haemonchus contortus eggs and larvae

机译：丙酮提取物和扁桃的馏分对变形弯形虫卵和幼虫的驱虫活性。

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The current control of parasitic nematodes in small ruminants relies on the use of chemical anthelminthics, but the development of resistance and the problem of drug residues require research into alternatives. Acetone extract and solvent-solvent fractions of Vernonia amygdalina Del. (Compositae) were evaluated in vitro for potential anti-parasitic effects against the eggs and larvae of Haemonchus contortus. Significant effects were obtained with the extract and fractions but differences were observed depending on the parasitic stage. The acetone extract and fractions inhibited egg hatching and inhibited larval development and killed larvae of H. contortus in a concentration-dependent manner. Best-fit 50% lethal concentration (LC sub(50)) values were 957.0, 76.0, 524.0, 309.0 and 224.0 mu g/ml for the acetone extract, and the butanol, hexane, chloroform and 35% water in methanol fractions, respectively, when tested against nematode eggs. Best-fit LC sub(50) values for the larval viability test were 508.2, 485.5, 569.3, 348.9 and 196.6 mu g/ml for the acetone extract, and the butanol, hexane, chloroform and 35% water in methanol fractions, respectively. The butanol fraction was most active against nematode eggs while the 35% water in methanol fraction was the most active on nematode larvae, although differences in activity between fractions were not significant (p>0.05). Overall, these in vitro results suggest that V. amygdalina, traditionally used by small farmers in Western Africa, does possess anti-parasitic properties.
机译：当前小反刍动物中寄生线虫的控制依靠化学驱虫药的使用，但是耐药性的发展和药物残留问题需要对替代方法进行研究。体外评价了Vernonia amygdalina Del。（Compositae）的丙酮提取物和溶剂-溶剂级分对扭蛋的潜在危害。提取物和馏分获得了显着效果，但观察到的差异取决于寄生虫的阶段。丙酮提取物和级分以浓度依赖的方式抑制卵孵化，抑制幼虫发育并杀死旋毛虫的幼虫。丙酮提取物以及甲醇馏分中的丁醇，己烷，氯仿和35％的水，最佳拟合50％致死浓度（LC sub（50））值分别为957.0、76.0、524.0、309.0和224.0μg / ml ，当针对线虫卵进行测试时。幼虫活力测试的最佳拟合LC sub（50）值分别是丙酮提取液和甲醇馏分中的丁醇，己烷，氯仿和35％的水，分别为508.2、485.5、569.3、348.9和196.6μg / ml。丁醇级分对线虫卵的活性最高，而甲醇级分中35％的水对线虫幼虫的活性最高，尽管级分之间的活性差异不显着（p> 0.05）。总体而言，这些体外结果表明，西非传统上由小农使用的扁桃扁桃体确实具有抗寄生虫特性。

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