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首页> 外文期刊>Tropical Animal Health and Production >Expression of skin color genes in lymphocytes of Karan Fries cattle and seasonal relationship with tyrosinase and cortisol
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Expression of skin color genes in lymphocytes of Karan Fries cattle and seasonal relationship with tyrosinase and cortisol

机译：Karan Fries牛淋巴细胞中肤色基因的表达及其与酪氨酸酶和皮质醇的季节性关系

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摘要

To evaluate difference in the expression of skin color genes (melanocortin 1 receptor (MC1R) and premelanosome (PMEL)) in lymphocytes during winter and summer season and their correlation with tyrosinase enzyme and cortisol, ten Karan-Fries heifers were selected from National Dairy Research Institute (NDRI) cattle farm. Blood samples were collected from the animals during winter (THI = 60) and summer (THI = 83) season at weekly intervals. Relative MC1R and PMEL messenger RNA (mRNA) expression of Karan Fries cattle was found to be significantly (P < 0.01) higher during winter than summer. Similarly, tyrosinase activity during winter was found to be significantly (P < 0.01) higher than summer season. However, plasma cortisol level was significantly (P < 0.01) higher during summer than winter. Thus, expression of the skin color genes showed positive correlation with tyrosinase enzyme, but negative correlation with cortisol level. Expression of MC1R and PMEL in lymphocytes and tyrosinase activity of Karan Fries cattle was highly reduced during summer. The present study showed that the ability of Karan Fries cattle to protect themselves from the harmful radiation of sunlight by melanization decreased with increased heat stress on them
机译：为了评估冬季和夏季淋巴细胞中肤色基因（黑皮质素1受体（MC1R）和黑素体（PMEL））的表达差异及其与酪氨酸酶和皮质醇的相关性，从美国国家乳业研究中选择了十只Karan-Fries母牛研究所（NDRI）的牛场。在冬季（THI = 60）和夏季（THI = 83）的季节每周一次从动物身上采集血液样本。据发现，Karan Fries牛的MC1R和PMEL信使RNA（mRNA）相对表达在冬季比夏季显着高（P <0.01）。同样，发现冬季的酪氨酸酶活性明显高于夏季（P <0.01）。然而，夏季血浆血浆皮质醇水平显着高于冬季（P <0.01）。因此，皮肤颜色基因的表达与酪氨酸酶呈正相关，而与皮质醇水平呈负相关。夏季，Karan Fries牛的淋巴细胞中MC1R和PMEL的表达和酪氨酸酶活性大大降低。本研究表明，Karan薯条牛通过黑化作用来保护自己免受日光有害辐射的能力会随着热量压力的增加而降低

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