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Campylobacter jejuni-microtubule-dependent invasion

机译:空肠弯曲菌依赖微管的侵袭

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Campylobacter jejuni is the leading bacterial cause of food-borne illness worldwide and a major cause of Guillain-Barre paralysis. Recent molecular and cellular studies of one well-characterized C. jejuni strain have begun to unravel the details of an unusual microtubule-dependent (actin-filament-independent) gut-invasion mechanism, through which at least some C. jejuni initiate disease. Although responsible for causing a human dysenteric syndrome remarkably similar to that triggered by Shigella spp., current evidence suggests that C. jejuni use some markedly different molecular mechanisms of pathogenesis compared with shigellae.
机译:空肠弯曲菌是全球食源性疾病的主要细菌病因,也是格林-巴利瘫痪的主要原因。最近对一种完全表征的空肠弯曲杆菌菌株的分子和细胞研究已经开始阐明异常的微管依赖性(独立于肌动蛋白丝)肠道侵袭机制的细节,至少一些空肠弯曲杆菌通过这种机制引发疾病。尽管造成人痢疾综合症的原因与志贺氏菌引起的异常相似,但目前的证据表明,空肠弯曲杆菌与志贺氏菌相比,使用了一些明显不同的分子机制。

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