Anthelmintic screening of fractions of Elephantorrhiza elephantina root extract against Haemonchus contortus.

Maphosa V.; Masika P. J.

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Anthelmintic screening of fractions of Elephantorrhiza elephantina root extract against Haemonchus contortus.

机译：麻风树elephant根提取物的抗寄生虫筛选。

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In the previous work conducted, it was found that the root extract of Elephantorrhiza elephantina (Bruch.) Skeels. exhibited good anthelmintic efficacy against eggs and larvae of Haemonchus contortus. This study was therefore undertaken to screen fractions of the extracts of E. elephantina for their anthelmintic activity against adult H. contortus using a bioactivity-guided assay. The adult worm bioassay was conducted using aqueous, hexane and ethyl acetate fractions of the plant extracts at concentrations of 0.312, 0.625, 1.25, 2.5, 5 and 10 mg/ml in vitro. Albendazole and distilled water were used as positive and negative control, respectively. In vitro treatment of adult worms revealed concentration and time-dependent efficacy of the fractions of E. elephantina. The aqueous and ethyl acetate fractions showed a highly significant (P<0.05) motility inhibition at concentrations of 2.5 mg/ml and above after 6 h of exposure, while the hexane fraction showed a significant (P<0.05) motility inhibition at concentrations of 5 mg/ml and above. After 30 h of exposure, all the fractions showed insignificant (P

机译：在先前进行的工作中，人们发现 Elephantorrhiza Elephantina （Bruch。）Skeels的根提取物。表现出良好的驱虫功效，可防治 Haemonchus contortus 的卵和幼虫。因此，进行了该研究以筛选E提取物的级分。 Elephantina 对成年 H的驱虫活性。使用生物活性指导的检测方法在体外使用浓度为0.312、0.625、1.25、2.5、5和10 mg / ml的植物提取物的水，己烷和乙酸乙酯馏分进行成虫实验。阿苯达唑和蒸馏水分别用作阳性和阴性对照。对成虫的体外治疗显示了组分的浓度和时间依赖性功效。大象。暴露6小时后，在2.5 mg / ml及以上的浓度下，含水和乙酸乙酯级分显示出高度显着的（ P <0.05）运动抑制性，而己烷级分显示出显着的（浓度在5 mg / ml及以上时，P 的死亡率指数和市售药物（阿苯达唑）也没有显着差异。总体而言，发现乙酸乙酯和含水部分具有最高的驱虫活性。因此，我们建议进行进一步的研究，以进一步研究这些组分在体内的有效剂量，以及对负责生物活性的化合物的全面研究。数字对象标识符http://dx.doi.org/10.1007/s11250-011- 9903-4 展开▼

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《Tropical Animal Health and Production》 |2012年第1期|共5页

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Maphosa V.; Masika P. J.;
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正文语种 eng

中图分类畜牧、动物医学、狩猎、蚕、蜂;

关键词
Efficacy; Fractions; Haemonchus contortus; Motility; Mortality;

机译：功效;分形;捻转血矛线虫;运动性;死亡率;

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专利

1. Anthelmintic screening of fractions of Elephantorrhiza elephantina root extract against Haemonchus contortus. [J] . Maphosa V., Masika P. J. Tropical Animal Health and Production . 2012,第1期

机译：麻风树elephant根提取物的抗寄生虫筛选。

2. In vitro screening of forty medicinal plant extracts from the United States Northern Great plains for anthelmintic activity against Haemonchus contortus. [J] . Acharya J., Hildreth M. B., Reese R. N. Veterinary Parasitology . 2014,第1a2期

机译：从美国北大平原的40种药用植物提取物中进行体外筛选，以研究其对弯曲杆菌（Haemonchus contortus）的驱虫活性。

3. In-vitro anthelminthic activity of crude aqueous extracts of Aloe ferox, Leonotis leonurus and Elephantorrhiza elephantina against Haemonchus contortus [J] . Viola Maphosa, Patrick J. Masika, Edmund S. Bizimenyera, Tropical Animal Health and Production . 2010,第2期

机译：芦荟，Leonotis leonurus和Elephantorrhiza Elephantina粗制水提物对捻转血矛线虫的体外驱虫活性

4. Comparative Efficacy of Various Anthelmintics against Haemonchus contortus in Goats [C] . Nasreen Akhter, Arijo A.G, Mirbahar K.B, 16th International congress on animal hygiene : animal hygiene, health and welfare as corner stones of sustainable animal production . 2013

机译：各种驱虫药对山羊变形杆菌的比较功效

5. EFFECTS OF MICROBES AND GASES ON THE FREE-LIVING STAGES OF TRICHOSTRONGYLUS COLUBRIFORMIS AND HAEMONCHUS CONTORTUS. [D] . WANG, GUANG-TSAN. 1968

机译：微生物和气体对毛状线虫和变形链球菌的生活阶段的影响。

6. In vitro efficacy of Elephantorrhiza elephantina root extracts against adult Paramphistomum cervi in goats [O] . Irene Rumbidzai Mazhangara, Patrick Julius Masika, John Fisher Mupangwa, 2020

机译：Elephantorrhiza elephantina根提取物对山羊成人旁术Cervi的体外疗效

7. In vitro anthelmintic effects of Spigelia anthelmia protein fractions against Haemonchus contortus. [O] . Sandra Alves Araújo, Alexandra Martins Dos Santos Soares, Carolina Rocha Silva, 2017

机译：spigelia anthelmia蛋白组分对捻转血矛线虫的体外驱虫作用。

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5. Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense [P] . 外国专利： DE4021428A1 . 1991-02-28

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Anthelmintic screening of fractions of Elephantorrhiza elephantina root extract against Haemonchus contortus.

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