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首页> 外文期刊>Tropical Animal Health and Production >Serum concentration of sialic acids in naturally occurring ovine babesiosis
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Serum concentration of sialic acids in naturally occurring ovine babesiosis

机译：自然发生的绵羊巴贝西虫病中唾液酸的血清浓度

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This study is designated to assess the effect of the severity of Babesia ovis infection on sialic acid concentration in blood sera in naturally infected sheep. Infected animals (diseased group) comprised 38 Iranian fat-tailed sheep, about 1-3 years old, naturally infected with B. ovis, divided into four subgroups with respect to parasitemia rates (low 0.1-0.3 %, moderate 0.4-0.9 %, high 1-2.5 %, and very high > 2.5 %). The parasitological diagnosis was confirmed using PCR analysis. As a control group, ten clinically healthy sheep reared under the same management and environmental conditions were also sampled. Hematological parameters and the concentrations of total sialic acid (TSA), lipid-bound sialic acid (LBSA), and protein-bound sialic acid (PBSA) were measured in both groups. Compared to controls, sialic acid concentrations showed significant increase (p < 0.05) in infected sheep. Parasitemia rate was positively correlated with sialic acid concentrations. This study demonstrated that B. ovis infection induced marked and persistent elevations of serum sialic acid concentrations. It seems that increase of serum sialic acid concentrations during parasitemia alter receptor-ligand interactions, which are known to play important role in immune response. Furthermore, sialic acid would indirectly inhibit the action of leukocytes and consequently promote the evasion of the immune response and persistence of the parasite in the host. This factor could influence the parasite-host cell adhesion, but further detailed biochemical investigations are needed to precisely explain the exact role of sialic acid in invasion process of the parasite to the host cells
机译：该研究旨在评估自然感染绵羊的绵羊巴贝斯虫感染严重程度对血液中唾液酸浓度的影响。受感染的动物（患病的组）包括38头约1-3岁的伊朗肥尾羊，它们自然感染了B. ovis，在寄生虫率方面分为四个亚组（低0.1-0.3％，中度0.4-0.9％，最高为1-2.5％，非常高> 2.5％）。寄生虫学诊断通过PCR分析得到证实。作为对照组，还取样了十只在相同管理和环境条件下饲养的临床健康绵羊。两组均测量血液学参数和总唾液酸（TSA），脂质结合唾液酸（LBSA）和蛋白质结合唾液酸（PBSA）的浓度。与对照组相比，感染绵羊的唾液酸浓度显着增加（p <0.05）。寄生虫率与唾液酸浓度呈正相关。这项研究表明，牛双歧杆菌感染可引起血清唾液酸浓度显着和持续升高。似乎在寄生虫病期间血清唾液酸浓度的增加改变了受体-配体的相互作用，这在免疫反应中起着重要的作用。此外，唾液酸将间接抑制白细胞的作用，从而促进免疫应答的逃避和宿主体内寄生虫的持久性。该因素可能影响寄生虫-宿主细胞的粘附，但需要进一步的详细生化研究以准确解释唾液酸在寄生虫侵袭宿主细胞过程中的确切作用。

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