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首页> 外文期刊>Trends in Neurosciences >The Muller cell: a functional element of the retina.
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The Muller cell: a functional element of the retina.

机译:穆勒细胞:视网膜的功能元件。

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摘要

Muller cells are the principal glial cells of the retina, assuming many of the functions carried out by astrocytes, oligodendrocytes and ependymal cells in other CNS regions. Muller cells express numerous voltage-gated channels and neurotransmitter receptors, which recognize a variety of neuronal signals and trigger cell depolarization and intracellular Ca2+ waves. In turn, Muller cells modulate neuronal activity by regulating the extracellular concentration of neuroactive substances, including: (1) K+, which is transported via Muller-cell spatial-buffering currents; (2) glutamate and GABA, which are taken up by Muller-cell high-affinity carriers; and (3) H+, which is controlled by the action of Muller-cell Na(+)-HCO3- co-transport and carbonic anhydrase. The two-way communication between Muller cells and retinal neurons indicates that Muller cells play an active role in retinal function.
机译:穆勒细胞是视网膜的主要神经胶质细胞,承担着其他中枢神经系统区域中的星形胶质细胞,少突胶质细胞和室管膜细胞执行的许多功能。穆勒细胞表达众多的电压门控通道和神经递质受体,可识别多种神经元信号并触发细胞去极化和细胞内Ca2 +波。反过来,穆勒细胞则通过调节神经活性物质的细胞外浓度来调节神经元活性,这些物质包括:(1)通过穆勒细胞空间缓冲电流转运的K +; (2)谷氨酸和GABA,被穆勒细胞高亲和力载体吸收; (3)H +,其受穆勒细胞Na(+)-HCO3-共转运和碳酸酐酶的作用控制。 Muller细胞和视网膜神经元之间的双向通讯表明Muller细胞在视网膜功能中起着积极的作用。

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