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首页> 外文期刊>Tropical Animal Health and Production >Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health
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Elimination of erythromycin in milk after intramammary administration in cows with specific mastitis: relation to dose, milking frequency and udder health

机译：患有特定乳腺炎的母牛在乳房内给药后消除牛奶中的红霉素：与剂量，挤奶频率和乳房健康的关系

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摘要

Elimination of erythromycin in milk following intramammary therapy of specific mastitis in cows was studied. Five cows received therapy in one quarter (G1), and eight in two quarters with five milked twice (G2) and three thrice a day (G3). Dose infused was 300mg/quarter 12h 5 times. The drug concentrations in milk were determined using microbial assay technique with Micrococcus luteus as the test organism. Considerable variations occurred in the excretion of drug; levels for treated quarters being 8.25 to 37.61 mu g/ml at first milking that declined rapidly at 24h and no drug activity was observed beyond 36h post treatment. In total, about 6-25% of the last infused dose appeared in the milk. Drug crossed to 1/15 quarter (G1), 6/10 quarters (G2) and all the six untreated quarters (G3). Crossover levels were significantly higher in mastitic quarters and for G3 cows, but duration of excretion remained same in all cases. It seems that crossover of erythromycin to untreated quarters is related to the udder health and dose infused.
机译：研究了在奶牛特定乳腺炎的乳房内治疗后消除牛奶中的红霉素。五分之一的奶牛在四分之一的时间里接受治疗（G1），四分之八的母牛接受了五次两次挤奶（G2），一天三次挤奶（G3）。剂量为300mg /季度12小时5次。牛奶中的药物浓度是使用微生物测定技术以黄曲霉作为测试生物体测定的。药物排泄发生了很大变化;刚开始挤奶时，处理季度的水含量为8.25至37.61μg / ml，在24小时迅速下降，并且在处理后36小时没有观察到药物活性。总体上，最后注入剂量的6-25％出现在牛奶中。药物跨过1/15季度（G1），6/10季度（G2）和所有六个未处理季度（G3）。乳香区和G3奶牛的交叉水平显着更高，但在所有情况下排泄的持续时间均相同。看来红霉素与未治疗的四分之一的交叉与乳房健康和注入的剂量有关。

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