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首页> 外文期刊>Tropical Animal Health and Production >A serological survey for antibodies against foot-and-mouth disease virus (FMDV) in domestic pigs during outbreaks in Kenya
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A serological survey for antibodies against foot-and-mouth disease virus (FMDV) in domestic pigs during outbreaks in Kenya

机译：肯尼亚爆发禽流感时对家猪口蹄疫病毒（FMDV）抗体的血清学调查

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摘要

Foot-and-mouth disease (FMD) is endemic in Kenya and has been well studied in cattle, but not in pigs, yet the role of pigs is recognised in FMD-free areas. This study investigated the presence of antibodies against FMD virus (FMDV) in pigs sampled during a countrywide random survey for FMD in cattle coinciding with SAT 1 FMDV outbreaks in cattle. A total of 191 serum samples were collected from clinically healthy pigs in 17 districts. Forty-two of the 191 sera were from pigs vaccinated against serotypes O/A/SAT 2 FMDV. Antibodies against FMDV non-structural proteins were found in sera from 30 vaccinated and 71 non-vaccinated pigs, altogether 101/191 sera (53 %), and 91 % of these (92/101) also had antibodies measurable by serotype-specific ELISAs, predominantly directed against SAT 1 with titres of 10-320. However, only five high titres against SAT 1 in vaccinated pigs were confirmed by virus neutralisation test (VNT). Due to high degree of agreement between the two ELISAs, it was concluded that positive pigs had been infected with FMDV. Implications of these results for the role of pigs in the epidemiology of FMD in Kenya are discussed, and in-depth studies are recommended.
机译：口蹄疫（FMD）在肯尼亚是地方病，已经在牛中进行了充分研究，但没有在猪中进行过研究，但是在无FMD的地区人们认识到了猪的作用。这项研究调查了在全国范围内对牛口蹄疫进行随机抽样调查的猪中，是否存在抗口蹄疫病毒（FMDV）的抗体，这与牛的SAT 1口蹄疫暴发相吻合。从17个地区的临床健康猪中总共采集了191个血清样本。 191个血清中有42个来自针对O / A / SAT 2 FMDV血清型接种的猪。在30头疫苗接种的猪和71头未接种疫苗的猪的血清中发现了针对FMDV非结构蛋白的抗体，共101/191血清（53％），其中91％（92/101）也具有可通过血清型特异性ELISA进行测量的抗体，主要针对SAT 1，滴度为10-320。但是，通过病毒中和试验（VNT）只能确认接种疫苗的猪中有5株抗SAT 1高滴度。由于两种ELISA之间的高度一致性，因此得出结论，阳性猪已被FMDV感染。讨论了这些结果对肯尼亚口蹄疫流行病学中猪的作用的影响，并建议进行深入研究。

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