Peripheral metabotropic glutamate receptors: fight the pain where it hurts.

Neugebauer V

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Peripheral metabotropic glutamate receptors: fight the pain where it hurts.

机译：周围代谢型谷氨酸受体：在疼痛处抵抗疼痛。

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Recent anatomical and behavioral data show the expression of G-protein coupled metabotropic glutamate receptors in the periphery on nociceptive primary afferent nerve terminals, and provide evidence for a functional role of peripheral metabotropic glutamate receptors in inflammatory pain. These findings have important implications for new therapeutic strategies that target peripheral metabotropic glutamate receptors for pain relief. They also alert us to the necessity of assessing drug effects at different levels of the nervous system: peripheral and central.

机译：最近的解剖学和行为学数据表明，伤害性初级传入神经末梢周围的G蛋白偶联代谢型谷氨酸受体在外周表达，并为周围型代谢型谷氨酸受体在炎性疼痛中的功能性作用提供了证据。这些发现对靶向外周代谢型谷氨酸受体以减轻疼痛的新治疗策略具有重要意义。他们还提醒我们必须评估神经系统不同水平（周围和中枢）的药物作用。

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《Trends in Neurosciences》 |2001年第10期|共3页
作者
Neugebauer V;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Peripheral; Receptors; Metabotropic Glutamate; 受体; 亲代谢性谷氨酸盐;

机译：Peripheral;Receptors;Metabotropic Glutamate;受体;亲代谢性谷氨酸盐;

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1. Peripheral metabotropic glutamate receptors: fight the pain where it hurts. [J] . Neugebauer V Trends in Neurosciences . 2001,第10期

机译：周围代谢型谷氨酸受体：在疼痛处抵抗疼痛。
2. Activation of peripheral group III metabotropic glutamate receptors inhibits pain transmission by decreasing neuronal excitability in the CFA-inflamed knee joint [J] . Park Eui Ho, Lee Seung Won, Moon Sun Wook, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2019,第期

机译：外周组III族代谢谷氨酸受体通过降低CFA发炎的膝关节中的神经元兴奋性来抑制疼痛传播
3. Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. [J] . Kumar N, Laferriere A, Yu JS, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2010,第1期

机译：代谢型谷氨酸受体（mGluRs）调节具有神经性和炎性疼痛的大鼠脊髓背角中有害刺激物诱导的谷氨酸释放。
4. Manifold learning visualization of Metabotropic Glutamate Receptors [C] . Martha-Ivon Cardenas, Alfredo Vellido, Jesus Giraldo International Conference of the Catalan Association for Artificial Intelligence . 2014

机译：代谢谷氨酸受体的歧管学习可视化
5. Metabotropic glutamate receptors in spinal cord injury: Roles in neuroprotection, chronic central pain, and locomotor recovery. [D] . Mills, Charles David. 2002

机译：代谢型谷氨酸受体在脊髓损伤中的作用：在神经保护，慢性中枢痛和运动恢复中的作用。
6. Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in spinal cord dorsal horn of rats with neuropathic and inflammatory pain [O] . Naresh Kumar, Andre Laferriere, Jonathan S.C. Yu, -1

机译：代谢谷氨酸受体（MGLURURS）调节有毒刺激诱导的脊髓背角在具有神经病和炎症疼痛的脊髓背角中的谷氨酸释放
7. 076 THE PERIPHERAL EFFECTS OF GROUP II AND III METABOTROPIC GLUTAMATE RECEPTORS ON KNEE JOINT ARTHRITIC PAIN IN RATS [O] . Lee M., Lee K., Park E., 2009

机译：076组II和组III代谢型谷氨酸盐受体对大鼠膝关节关节痛的影响

Peripheral metabotropic glutamate receptors: fight the pain where it hurts.

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