Transcriptional dysregulation in Huntington's disease.

Cha JH

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Transcriptional dysregulation in Huntington's disease.

机译：亨廷顿舞蹈病的转录异常。

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Although the gene responsible for Huntington's disease was discovered in 1993, the pathogenic mechanisms by which mutant huntingtin causes neuronal dysfunction and death remain unclear. However, increasing evidence suggests that mutant huntingtin disrupts the normal transcriptional program of susceptible neurons. Thus, transcriptional dysregulation might be an important pathogenic mechanism in Huntington's disease.

机译：尽管导致亨廷顿氏病的基因是在1993年发现的，但亨廷顿突变体引起神经元功能障碍和死亡的致病机制仍不清楚。但是，越来越多的证据表明，亨廷顿突变体会破坏易感神经元的正常转录程序。因此，转录失调可能是亨廷顿氏病的重要致病机制。

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《Trends in Neurosciences》 |2000年第9期|共6页
作者
Cha JH;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Huntington Disease genetics; Huntington Disease physiopathology; Transcription; Genetic; 转录; 遗传;

机译：Huntington Disease genetics;Huntington Disease physiopathology;Transcription;Genetic;转录;遗传;

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专利

1. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. [J] . Neurobiology of disease . 2008,第3期

机译：亨廷顿氏病中，纹状体丰富的转录因子Bcl11b在控制纹状体基因表达和转录失调中的功能性作用。
2. The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. [J] . Buckley NJ, Johnson R, Zuccato C, Neurobiology of disease . 2010,第1期

机译：REST在亨廷顿氏病的转录和表观遗传异常中的作用。
3. Transcriptional dysregulation in Huntington's disease. [J] . Cha JH Trends in Neurosciences . 2000,第9期

机译：亨廷顿舞蹈病的转录异常。
4. A Novel Parameterisation of Phase Plots for Monitoring of Parkinson’s Disease. [C] . Michael Dunne-Willows, Paul Watson, Jian Shi, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：用于监测帕金森氏病的新型相图参数化。
5. Therapeutic implications of mutant huntingtin-induced dysregulation of brain iron homeostasis in a mouse model of Huntington's disease. [D] . Marks, Eileen S. 2011

机译：亨廷顿氏病小鼠模型中突变亨廷顿蛋白诱导的脑铁稳态失调的治疗意义。
6. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease [O] . Bin Tang, Kristina Becanovic, Paula A. Desplats, -1

机译：前叉箱蛋白p1是中枢神经系统免疫信号的转录阻遏物：对亨廷顿病转录失调的影响
7. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease [O] . Bin Tang, Kristina Becanovic, Paula A. Desplats, 2012

机译：Forkhead盒蛋白P1是CNS中免疫信号传导的转录阻遏物：对亨廷顿病的转录失调的影响

Transcriptional dysregulation in Huntington's disease.

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