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首页> 外文期刊>Tropical Animal Health and Production >Prophylactic and therapeutic effects of a novel granulated formulation of Artemisia extract on broiler coccidiosis.
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Prophylactic and therapeutic effects of a novel granulated formulation of Artemisia extract on broiler coccidiosis.

机译：一种新型颗粒状蒿提取物的制剂对肉鸡球虫病的预防和治疗作用。

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Purpose: Coccidiosis is an important parasitic disease in poultry industry. Owing to the development of drug resistance against Eimeria and concerns about drug residues, attentions toward the alternative compounds including herbal medicines have been increased. This study aimed to examine the prophylactic and therapeutic effects of a new formulation derived from Artemisia sieberi extract on avian coccidiosis. Methods: The extract was obtained from A. sieberi using petroleum ether, and then, it was formulated into a wet granule. Three hundred and sixty 1-day-old broilers were divided into six groups, each with three replicates (n=20); the first group was chosen as the noninfected control group and the remainders were challenged by oral administration of 250,000 oocysts of Eimeria tenella per chick on day 21. Group 2 (as nontreated control) received no treatment, but group 3 (as prophylactic group) received 0.5 mg/kg artemisinin 10 days before challenging with E. tenella. However, groups 4, 5, and 6 received 1 mg/kg artemisinin on the next day and at 24 and 48 h after the challenge, respectively, for 5 days. Mortality rate, bloody diarrhea score, lesion score, and oocysts per gram (OPG) of feces were used to determine the anticoccidial effects of the formulation. Results: The granule significantly (p<0.05) reduced mortality, diarrhea, and lesion score in the treated groups. The OPG output was also significantly (p<0.0001) reduced in the groups that received formulation. However, there was no significant difference between the prophylactic and therapeutic groups. Conclusion: The results suggested that this new formulation is a promising herbal medicine that can be used as a prophylactic or therapeutic product to control avian coccidiosis.
机译：目的：球虫病是家禽业中一种重要的寄生虫病。由于对艾美球虫的抗药性的发展以及对药物残留的关注，人们对包括草药在内的替代化合物的关注日益增加。这项研究旨在检查源自西伯利亚蒿提取物的新配方对禽球虫病的预防和治疗作用。方法：用石油醚从西伯利亚曲霉中提取提取物，然后配制成湿颗粒。将360只1天大的肉鸡分成6组，每组重复3次（n = 20）。第一组被选为未感染的对照组，其余的则在第21天通过每只小鸡口服25万个艾美球虫卵囊进行攻击。第2组（作为未治疗的对照组）未接受治疗，但第3组（作为预防组）接受了治疗0.5 mg / kg青蒿素在用大肠杆菌进行攻击前10天。但是，第4、5和6组在攻击的第二天，攻击后24小时和48小时分别接受1 mg / kg青蒿素治疗5天。死亡率，血液腹泻评分，病变评分和每克粪便中的卵囊（OPG）用于确定制剂的抗球虫作用。结果：在治疗组中，该颗粒显着（p <0.05）降低了死亡率，腹泻和病变评分。在接受配方的组中，OPG的输出也显着降低（p <0.0001）。但是，预防组和治疗组之间没有显着差异。结论：结果表明，这种新配方是一种很有前途的草药，可以用作预防或治疗禽类球虫病的产品。

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